Powder: -20°C for 3 years
In solvent: -80°C for 2 years
OAC1 is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.
Description | OAC1 is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process. |
Kinase Assay | Enzymology: Kinesin motor domains are expressed in Escherichia coli BL21(DE3) and purified. CENP-E proteins includes residues 2–340 with a carboxyl-terminal 6-his tag. All studies using MT are conducted in PEM25 buffer [25 mM PipesK+ (pH 6.8), 2 mM MgCl2, 1 mM EGTA] supplemented with 10 μM paclitaxel. The IC50 for steady-state inhibition is determined at 500 μM ATP, 5 μM MT, and 1 nM CENP-E in PEM25 buffer. |
Cell Research | The Oct4-luc or Nanog-luc cells are treated with compound OAC1 at 1 μM concentration. Luciferase reporter assays are performed 24 h after OAC1 treatment.(Only for Reference) |
Synonyms | BAS 00287861 |
Molecular Weight | 237.262 |
Formula | C14H11N3O |
CAS No. | 300586-90-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: 23.7 mg/mL (100 mM)
DMSO: 23.7 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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OAC1 300586-90-7 离子通道 OCT inhibit OAC 1 induced pluripotent stem cells HOXB4 Slc22a3 POU5F1 Oct3/4 Inhibitor human IMR90 fibroblast cells BAS 00287861 CD34+cells OAC-1 Nanog promoters reprogramming inhibitor