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OAC1

Catalog No. T2040 CAS 300586-90-7

Synonyms: BAS 00287861

OAC1 is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.

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OAC1, CAS 300586-90-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	OAC1 is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.
Kinase Assay	Enzymology: Kinesin motor domains are expressed in Escherichia coli BL21(DE3) and purified. CENP-E proteins includes residues 2–340 with a carboxyl-terminal 6-his tag. All studies using MT are conducted in PEM25 buffer [25 mM PipesK+ (pH 6.8), 2 mM MgCl2, 1 mM EGTA] supplemented with 10 μM paclitaxel. The IC50 for steady-state inhibition is determined at 500 μM ATP, 5 μM MT, and 1 nM CENP-E in PEM25 buffer.
Cell Research	The Oct4-luc or Nanog-luc cells are treated with compound OAC1 at 1 μM concentration. Luciferase reporter assays are performed 24 h after OAC1 treatment.(Only for Reference)

Synonyms	BAS 00287861
Molecular Weight	237.262
Formula	C14H11N3O
CAS No.	300586-90-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 23.7 mg/mL (100 mM)

DMSO: 23.7 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Li W, et al. Proc Natl Acad Sci U S A, 2012, 109(51), 20853-20858.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Ion Channel Inhibitor Library Stem Cell Differentiation Compound Library Anti-Aging Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Retrorsine 3-O-Methylgallic acid Jatrorrhizine chloride Oct3/4-inducer-1 O4I1 O4I2 OAC1 OAC2

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

OAC1 300586-90-7 离子通道 OCT inhibit OAC 1 induced pluripotent stem cells HOXB4 Slc22a3 POU5F1 Oct3/4 Inhibitor human IMR90 fibroblast cells BAS 00287861 CD34+cells OAC-1 Nanog promoters reprogramming inhibitor

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