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OAC1
🥰Excellent
Catalog No. T2040Cas No. 300586-90-7
Alias BAS 00287861
OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.
OAC1
🥰Excellent
Purity: 99.65%
Catalog No. T2040Alias BAS 00287861Cas No. 300586-90-7
OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 2 mg | $42 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $176 | In Stock | |
| 50 mg | $333 | In Stock | |
| 100 mg | $600 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $64 | In Stock |
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Purity:99.65%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process. |
| In vivo | OAC1 appears to enhance reprogramming efficiency by increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. OAC1 does not inhibit the p53-p21 pathway or activate Wnt-β-catenin signaling.OAC1 can be used to enhance the reprogramming of somatic cells to a pluripotent state.1 μM OAC1 enhances the reprogramming efficiency by activating the Oct4 and Nanog promoter-driven luciferase reporter genes. In addition, OAC1 enhanced the reprogramming efficiency and accelerated the reprogramming process of pluripotent stem cells (iPSCs) in mouse embryonic fibroblasts (MEFs) treated with four reprogramming factors (Oct4, Sox2, c-Myc and Klf4). |
| Kinase Assay | Enzymology: Kinesin motor domains are expressed in Escherichia coli BL21(DE3) and purified. CENP-E proteins includes residues 2–340 with a carboxyl-terminal 6-his tag. All studies using MT are conducted in PEM25 buffer [25 mM PipesK+ (pH 6.8), 2 mM MgCl2, 1 mM EGTA] supplemented with 10 μM paclitaxel. The IC50 for steady-state inhibition is determined at 500 μM ATP, 5 μM MT, and 1 nM CENP-E in PEM25 buffer. |
| Cell Research | The Oct4-luc or Nanog-luc cells are treated with compound OAC1 at 1 μM concentration. Luciferase reporter assays are performed 24 h after OAC1 treatment.(Only for Reference) |
| Alias | BAS 00287861 |
| Molecular Weight | 237.26 |
| Formula | C14H11N3O |
| Cas No. | 300586-90-7 |
| Smiles | O=C(Nc1cc2cc[nH]c2cn1)c1ccccc1 |
| Relative Density. | 1.363 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 23.7 mg/mL (99.89 mM), Sonication is recommended. DMSO: 23.7 mg/mL (99.89 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
Ethanol/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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