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Naproxcinod

Catalog No. T33595 CAS 163133-43-5

Synonyms: AZD3582, Nitronaproxen, AZD-3582, Naproxen-N-butyl nitrate, HCT3012, AZD 3582

Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in the myocardium and diaphragm. In addition to its anti-inflammatory activity, Naproxcinod is a promising candidate for the treatment of Duchenne muscular dystrophy.

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Naproxcinod, CAS 163133-43-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	AZD3582, Nitronaproxen, AZD-3582, Naproxen-N-butyl nitrate, HCT3012, AZD 3582
Molecular Weight	347.36
Formula	C18H21NO6
CAS No.	163133-43-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Miglietta D, De Palma C, Sciorati C, Vergani B, Pisa V, Villa A, Ongini E, Clementi E. Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy. Orphanet J Rare Dis. 2015 Aug 22;10:101. doi: 10.1186/s13023-015-0311-0. PubMed PMID: 26296873; PubMed Central PMCID: PMC4546261. 2. Li X, Zhang J, Bao Y, Ye Y, Li W, Yin W, Guo F, Chen A. WITHDRAWN: Efficacy and safety of short-term treatment of naproxcinod in patients with osteoarthritis (OA) of the hip: A prospective, randomized study. Arch Gerontol Geriatr. 2015 Jan 31. pii: S0167-4943(15)00013-8. doi: 10.1016/j.archger.2015.01.012. [Epub ahead of print] PubMed PMID: 25912890. 3. Shi X, Shang W, Wang S, Xue N, Hao Y, Wang Y, Sun M, Du Y, Cao D, Zhang K, Shi Q. Simultaneous quantification of naproxcinod and its active metabolite naproxen in rat plasma using LC-MS/MS: application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 26;978-979:157-62. doi: 10.1016/j.jchromb.2014.12.001. Epub 2014 Dec 11. PubMed PMID: 25550191. 4. Uaesoontrachoon K, Quinn JL, Tatem KS, Van Der Meulen JH, Yu Q, Phadke A, Miller BK, Gordish-Dressman H, Ongini E, Miglietta D, Nagaraju K. Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy. Hum Mol Genet. 2014 Jun 15;23(12):3239-49. doi: 10.1093/hmg/ddu033. Epub 2014 Jan 23. PubMed PMID: 24463621; PubMed Central PMCID: PMC4030778.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Naproxcinod 163133-43-5 Naproxen-N-butyl Nitrate AZD3582 Nitronaproxen AZD-3582 HCT-3012 Naproxen-N-butyl nitrate HCT3012 HCT 3012 AZD 3582 inhibitor inhibit

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