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Nafoxidine
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Catalog No. T21387LCas No. 1845-11-0
Nafoxidine is an estrogen antagonist that has been used in the treatment of breast cancer.
Nafoxidine
Copy Product Info🥰Excellent
Purity: 99.93%
Catalog No. T21387LCas No. 1845-11-0
Nafoxidine is an estrogen antagonist that has been used in the treatment of breast cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $36 | In Stock | In Stock | |
| 10 mg | $53 | In Stock | In Stock | |
| 25 mg | $98 | In Stock | In Stock | |
| 50 mg | $155 | In Stock | In Stock | |
| 100 mg | $248 | In Stock | In Stock | |
| 200 mg | $368 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.93%
Appearance:Solid
Color:Yellow
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Product Introduction
Nafoxidine AI Summary
Nafoxidine exhibits a multifaceted bioactivity profile. It shows uterotrophic activity in rats relative to estradiol with a relative activity of 5.5 and demonstrates a relative binding affinity (RBA) for uterine cytosolic estrogen receptors of immature rats at 9.29%. Additionally, it possesses antiimplantation activity in sperm-positive female rats at a minimum effective dose of 0.1 mg kg^-1. The compound also exhibits antiestrogenic effects, inhibiting estrus in ovariectomized rats treated with 17-beta-estradiol with an inhibition rate of 44.0%, and prevents estradiol binding to estrogen receptors with an IC50 of 40.9 nM.
In terms of binding affinity, Nafoxidine shows an RBA of 183.0 for chicken liver, 90.0 for rat liver, and 124.0 for guinea pig uterus, suggesting strong antiestrogenic potential. It also binds to human EMP and sigma receptor type 1 with Ki values of 0.9 nM and 30.0 nM, respectively, and exhibits affinity for ERG2 in Saccharomyces cerevisiae with a Ki of 232.0 nM. Against the recombinant rat androgen receptor, it has an IC50 of 12882.5 nM.
Further, Nafoxidine demonstrates antiviral activity in different contexts. Against SARS-CoV-2, it exhibits an IC50 > 100000.0 nM, indicating weak potency, and shows a CC50 of 3850.0 nM in VERO-E6 cells. It also inhibits pseudotyped Marburgvirus and Ebola virus strains in human A549 cells with varied IC50 values, highlighting its selective antiviral potential. This compound's complex bioactivity profile suggests potential applications in estrogen receptor modulation, antiviral therapies, and antiestrogenic treatments..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nafoxidine is an estrogen antagonist that has been used in the treatment of breast cancer. |
| Molecular Weight | 425.56 |
| Formula | C29H31NO2 |
| Cas No. | 1845-11-0 |
| Smiles | O(C)C=1C=C2C(C(=C(CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1 |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 65 mg/mL (152.74 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.7 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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