Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NTRC-0066-0 is a a highly potent and selective inhibitor of TTK. NTRC 0066-0 inhibits the phosphorylation of a TTK substrate and induces chromosome missegregation. NTRC 0066-0 inhibits tumor growth in MDA-MB-231 xenografts as a single agent after oral application. The combination of NTRC 0066-0 with a therapeutic dose of docetaxel resulted in doubling of mouse survival and extended tumor remission, without toxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | 8-10 weeks | $ 719.00 | |
100 mg | 8-10 weeks | $ 995.00 |
Description | NTRC-0066-0 is a a highly potent and selective inhibitor of TTK. NTRC 0066-0 inhibits the phosphorylation of a TTK substrate and induces chromosome missegregation. NTRC 0066-0 inhibits tumor growth in MDA-MB-231 xenografts as a single agent after oral application. The combination of NTRC 0066-0 with a therapeutic dose of docetaxel resulted in doubling of mouse survival and extended tumor remission, without toxicity. |
Targets&IC50 | TTK:0.9 nM (IC50) |
Synonyms | NTRC-0066-0, NTRC-00660, NTRC00660, NTRC0066-0 |
Molecular Weight | 565.71 |
Formula | C33H39N7O2 |
CAS No. | 1817791-73-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NTRC 0066-0 1817791-73-3 NTRC-0066-0 NTRC 00660 NTRC 0066 0 NTRC-00660 NTRC00660 NTRC0066-0 inhibitor inhibit