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NSC 23766

Catalog No. T40848 CAS 733767-34-5

NSC 23766, a cell-permeable compound, is a reversible and specific inhibitor of Rac GTPase. Its primary application lies in the field of cancer treatment.

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NSC 23766, CAS 733767-34-5

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 40.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	NSC 23766, a cell-permeable compound, is a reversible and specific inhibitor of Rac GTPase. Its primary application lies in the field of cancer treatment.
In vitro	NSC 23766 (100?μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased[2]. NSC23766 (50?μM) plus 100?ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles[3]. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons[4].
In vivo	NSC23766, administered intraperitoneally at a dosage of 2.5 mg/kg/day, markedly delays the onset of spontaneous diabetes in NOD mice without notably influencing their growth, as measured by body weights. Furthermore, this compound significantly elevates the expression levels of Rac1 and CHOP, an endoplasmic reticulum (ER) stress marker, in the islets of NOD mice[1].

Molecular Weight	421.58
Formula	C24H35N7
CAS No.	733767-34-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39(2):760-7. 2. Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415 3. Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972 4. Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173(5):937-50

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NSC 23766 733767-34-5 NSC-23766 NSC23766 inhibitor inhibit

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