Shopping Cart
- Remove All
Your shopping cart is currently empty
NSC16168
🥰Excellent
Catalog No. T16351Cas No. 6837-93-0
Alias NSC 16168
NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.
NSC16168
🥰Excellent
Purity: 99.88%
Catalog No. T16351Alias NSC 16168Cas No. 6837-93-0
NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $139 | In Stock | |
| 10 mg | $222 | In Stock | |
| 25 mg | $375 | In Stock | |
| 50 mg | $552 | In Stock | |
| 100 mg | $787 | In Stock | |
| 200 mg | $1,070 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $166 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "NSC16168"
Methoxsalen
Xanthotoxin, NCI-C55903, 8-MOP, 8-Methoxypsoralen
T1548298-81-7
Methoxsalen (NCI-C55903) is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.
- $29
Size
QTY
Chromium picolinate
Cited
T457514639-25-9
Chromium picolinate causes DNA damage and mutation. It is an activator of p38.
- $41
Size
QTY
CitedProflavine Hemisulfate
Proflavin hemisulfate, 3,6-Diaminoacridine hemisulfate
T04381811-28-5
Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and antiseptic purposes.
- $33
Size
QTY
Cyclophosphamide Cited
T0707L50-18-0
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
- $35
Size
QTY
CitedL82
T60753329227-30-7In house
L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
- $64
Size
QTY
Quinacrine dihydrochloride Cited
SN-390, Quinacrine 2HCl, Mepacrine dihydrochloride
T094269-05-6
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
- $41
Size
QTY
CitedHydroxychloroquine sulfate Cited
HCQ sulfate, Acidum iopanoicum
T0951747-36-4
Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.
- $48
Size
QTY
CitedNorharmane
β-Carboline, 2-Azacarbazole, 2,9-Diazafluorene
T4024244-63-3
Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
- $30
Size
QTY
Crystal Violet Cited
Methyl Violet 10B, Hexamethylpararosaniline chloride, Gentian Violet, Basic Violet 3
T1343L548-62-9
Crystal Violet (Hexamethylpararosaniline chloride) is a triarylmethane dye that is a mixture of violet rosanilinis, with antibacterial, antifungal, and anthelmintic properties.
- $46
Size
QTY
CitedCyclophosphamide hydrate Cited
Cyclophosphamide monohydrate
T07076055-19-2
Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
- $33
Size
QTY
CitedClofazimine Cited
NSC-141046
T03772030-63-9
Clofazimine (NSC-141046) is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.
- $50
Size
QTY
Cited
Select Batch
Purity:99.88%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin. |
| Targets&IC50 | ERCC1 XPF:0.42 μM |
| In vitro | NSC16168 is a specific inhibitor of ERCC1-XPF with an IC50 of 0.42 μM. NSC16168 potentiates the antitumor effect of cisplatin on cancer cells in the concentration range of 0-50 μM. [1] |
| In vivo | In the H460 lung cancer xenograft model, NSC16168 was injected intraperitoneally twice a day at a dose of 20 mg/kg and showed significant antitumor effects and synergistically enhanced the efficacy of cisplatin. [1] |
| Alias | NSC 16168 |
| Molecular Weight | 473.5 |
| Formula | C17H15NO9S3 |
| Cas No. | 6837-93-0 |
| Smiles | O=S(=O)(O)C=1C=C(OS(=O)(=O)C2=CC=C(C=C2)C)C3=C(N)C=C(C=C3C1)S(=O)(=O)O |
| Relative Density. | 1.5197 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (42.24 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Sci Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy NSC16168 | purchase NSC16168 | NSC16168 cost | order NSC16168 | NSC16168 chemical structure | NSC16168 in vivo | NSC16168 in vitro | NSC16168 formula | NSC16168 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.