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Catalog No. T12252   CAS 204718-47-8

NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)

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NRA-0160 Chemical Structure
NRA-0160, CAS 204718-47-8
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50 mg 6-8 weeks $ 1,980.00
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Biological Description
Chemical Properties
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Description NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
Targets&IC50 α1-adrenoceptor (rat):237 nM (ki), D4 receptor:0.48 nM (ki), D3 receptor:39 nM (ki), 5-HT2A receptor:180 nM (Ki, in rat)
In vivo NRA0160 dose-dependently and significantly reverses the effects of MAP on both A9 and Al0 dopamine neurons.?NRA0160 is slightly more potent in reversiig the effects of MAP on A10 (ED50 = 1.0 mg/kg) than on A9 dopamine neurons (ED50 = 1.3 mg/kg).?NRA0160 reverses the effect of AP0 on both A9 and A10 dopamine neurons.?ED50 values for the effects of NRA0160 on APO-induced inhibition of A9 and A10 dopamine neurons are 1.3 mg/kg and 0.5 mg/kg, respectively[2].
Molecular Weight 439.52
Formula C24H23F2N3OS
CAS No. 204718-47-8


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Abekawa T, et al. Effects of NRA0045, a novel potent antagonist at dopamine D4, 5-HT2A, and alpha1 adrenaline receptors, and NRA0160, a selective D4 receptor antagonist, on phencyclidine-induced behavior and glutamate release in rats. Psychopharmacology (Berl). 2003 Sep;169(3-4):247-56. Epub 2003 Jul 31. 2. Kawashima N, et al. Effects of selective dopamine D4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats. Life Sci. 1999;65(24):2561-71.

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NRA-0160 204718-47-8 GPCR/G Protein Neuroscience Dopamine Receptor NRA 0160 NRA0160 inhibitor inhibit