Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of <57 μM, 22.8 μM, 20.1 μM, <57 μM respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 413.00 | |
10 mg | In stock | $ 618.00 | |
25 mg | In stock | $ 985.00 | |
50 mg | In stock | $ 1,330.00 | |
100 mg | In stock | $ 1,790.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 475.00 |
Description | NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, >57 μM respectively. |
Targets&IC50 | ALDH2 (human):20.1 μM , ALDH1A1:7 nM , ALDH1A3 (human):22.8 μM , ALDH1A2 (human):>57 μM , ALDH3A1 (human):>57 μM |
In vitro | NCT-505 (compound 86) is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor with IC50 of 7 nM, weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM ). NCT-505 has no significant inhibitory effect on 5-hydroxyprostaglandin dehydrogenase (HPGD) and type 4 hydroxysteroid dehydrogenase (HSD17β4) (IC50, >57 μM). In addition, NCT-505 showed potent cellular viability, reducing the viability of OV-90 cells with EC50 of 2.10-3.92 μM. NCT-505 is also cytotoxic to SKOV-3-TR cells with IC50 of 1, 3, 10, 20, 30 μM in titration analysis[1]. |
Molecular Weight | 521.61 |
Formula | C27H28FN5O3S |
CAS No. | 2231079-74-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (105.44 mM)
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NCT-505 2231079-74-4 Metabolism Dehydrogenase inhibit NCT505 Aldehyde Dehydrogenase (ALDH) Inhibitor NCT 505 inhibitor