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N-Acetyl-L-cysteine ethyl ester

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N-Acetyl-L-cysteine ethyl ester

Catalog No. T41285Cas No. 59587-09-6

N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid-L-cysteine. N-Acetyl-L-cysteine ethyl ester has been shown to have a wide range of biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. It has also been shown to have anti-inflammatory, anti-oxidant, and anti-cancer activity.

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Pack Size	Price	Availability
10 mg	$40	7-10 days
25 mg	$71	7-10 days
50 mg	$113	7-10 days
100 mg	$198	7-10 days
500 mg	$515	7-10 days
1 mL x 10 mM (in DMSO)	$44	7-10 days

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Product Introduction

Bioactivity

Description	N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid-L-cysteine. N-Acetyl-L-cysteine ethyl ester has been shown to have a wide range of biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. It has also been shown to have anti-inflammatory, anti-oxidant, and anti-cancer activity.
In vitro	Under concomitant oxidative stress induced by 2 mM H2O2, N-Acetyl-L-cysteine ethyl ester (NACET) showed strong and significant protective effect on RPE cells when the concentration was 0.4 mM. Moreover, NACET treatment also resulted in an enhanced protective effect when RPE cells were stressed by the organic ROS generator peroxide tert-Butyl hydroperoxide (t-BOOH).NACET significantly increased both intracellular GSH and cysteine at 0.2 and 1 mM concentrations, respectively, as well as extracellular total GSH[2].
Alias	NACET, N-Acetylcysteine ethyl ester

Chemical Properties

Molecular Weight	191.25
Formula	C7H13NO3S
Cas No.	59587-09-6

Storage & Solubility Information

Storage

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (235.3 mM), Sonication is recommended.

H2O: 90.0 mg/mL (470.6 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2288 mL	26.1438 mL	52.2876 mL	261.4379 mL
5 mM	1.0458 mL	5.2288 mL	10.4575 mL	52.2876 mL
10 mM	0.5229 mL	2.6144 mL	5.2288 mL	26.1438 mL
20 mM	0.2614 mL	1.3072 mL	2.6144 mL	13.0719 mL
50 mM	0.1046 mL	0.5229 mL	1.0458 mL	5.2288 mL
100 mM	0.0523 mL	0.2614 mL	0.5229 mL	2.6144 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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