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N-Acetyl-L-cysteine ethyl ester

Catalog No. T41285   CAS 59587-09-6
Synonyms: NACET, N-Acetylcysteine ethyl ester

N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid-L-cysteine. N-Acetyl-L-cysteine ethyl ester has been shown to have a wide range of biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. It has also been shown to have anti-inflammatory, anti-oxidant, and anti-cancer activity.

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N-Acetyl-L-cysteine ethyl ester Chemical Structure
N-Acetyl-L-cysteine ethyl ester, CAS 59587-09-6
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Biological Description
Chemical Properties
Storage & Solubility Information
Description N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid-L-cysteine. N-Acetyl-L-cysteine ethyl ester has been shown to have a wide range of biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. It has also been shown to have anti-inflammatory, anti-oxidant, and anti-cancer activity.
In vitro Under concomitant oxidative stress induced by 2 mM H2O2, N-Acetyl-L-cysteine ethyl ester (NACET) showed strong and significant protective effect on RPE cells when the concentration was 0.4 mM. Moreover, NACET treatment also resulted in an enhanced protective effect when RPE cells were stressed by the organic ROS generator peroxide tert-Butyl hydroperoxide (t-BOOH).NACET significantly increased both intracellular GSH and cysteine at 0.2 and 1 mM concentrations, respectively, as well as extracellular total GSH[2].
Synonyms NACET, N-Acetylcysteine ethyl ester
Molecular Weight 191.25
Formula C7H13NO3S
CAS No. 59587-09-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (235.3 mM), Need ultrasonic

H2O: 90.0 mg/mL (470.6 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Giustarini D, et al. N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential. Biochem Pharmacol. 2012 Dec 1;84(11):1522-33. 2. Tosi GM, et al. Superior Properties of N-Acetylcysteine Ethyl Ester over N-Acetyl Cysteine to Prevent Retinal Pigment Epithelial Cells Oxidative Damage. Int J Mol Sci. 2021 Jan 9;22(2):600.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library

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Keywords

N-Acetyl-L-cysteine ethyl ester 59587-09-6 oxidation-reduction Antioxidant NACET N-Acetylcysteine ethyl ester inhibitor inhibit

 

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