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Mozavaptan hydrochloride

Catalog No. T21465 CAS 138470-70-9

Synonyms: OPC-31260, OPC31260, Mozavaptan HCl, OPC 31260

Mozavaptan is a vasopressin receptor antagonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Mozavaptan hydrochloride Chemical Structure

Mozavaptan hydrochloride, CAS 138470-70-9

Pack Size	Availability	Price/USD	Quantity
5 mg	5 days	$ 38.00
1 mL * 10 mM (in DMSO)	5 days	$ 52.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mozavaptan is a vasopressin receptor antagonist.
Targets&IC50	V1 receptor:1.2 μM (IC50), V2 receptor:14 nM (IC50)

Synonyms	OPC-31260, OPC31260, Mozavaptan HCl, OPC 31260
Molecular Weight	464
Formula	C27H30ClN3O2
CAS No.	138470-70-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: Soluble

References and Literature

1. Yamazaki T, Fukata A, Muraki Y. Imidafenacin exerts the antidiuretic effect by enhancing vasopressin-related responses in orally water-loaded rats. Eur J Pharmacol. 2016 Nov 15;791:72-77. doi: 10.1016/j.ejphar.2016.08.021. PubMed PMID: 27568834. 2. Sharif SA, Calder ED, Delolo FG, Sutherland A. Synthesis of 5-Amino-2,5-dihydro-1H-benzo[b]azepines Using a One-Pot Multibond Forming Process. J Org Chem. 2016 Aug 5;81(15):6697-706. doi: 10.1021/acs.joc.6b01357. PubMed PMID: 27414232. 3. Tabata K, Nishimura Y, Takeda T, Kurita M, Uchiyama T, Suzuki T. Sesquiterpene lactones derived from Saussurea lappa induce apoptosis and inhibit invasion and migration in neuroblastoma cells. J Pharmacol Sci. 2015 Apr;127(4):397-403. doi: 10.1016/j.jphs.2015.01.002. PubMed PMID: 25953266. 4. Verbalis JG, Grossman A, Höybye C, Runkle I. Review and analysis of differing regulatory indications and expert panel guidelines for the treatment of hyponatremia. Curr Med Res Opin. 2014 Jul;30(7):1201-7. doi: 10.1185/03007995.2014.920314. Review. PubMed PMID: 24809970.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molecular Weight Calculator

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mozavaptan hydrochloride 138470-70-9 OPC-31260 Mozavaptan Hydrochloride OPC31260 Mozavaptan HCl OPC 31260 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.