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Mnm5s2U

Catalog No. T33463 CAS 32860-54-1

Synonyms: mnm-5s2U, mnm 5s2U

Mnm5s2U is a hypermodified nucleoside.

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Mnm5s2U, CAS 32860-54-1

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Mnm5s2U is a hypermodified nucleoside.

Synonyms	mnm-5s2U, mnm 5s2U
Molecular Weight	303.33
Formula	C11H17N3O5S
CAS No.	32860-54-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Pearson D, Carell T. Assay of both activities of the bifunctional tRNA-modifying enzyme MnmC reveals a kinetic basis for selective full modification of cmnm5s2U to mnm5s2U. Nucleic Acids Res. 2011 Jun;39(11):4818-26. doi: 10.1093/nar/gkr071. Epub 2011 Feb 8. PubMed PMID: 21306992; PubMed Central PMCID: PMC3113582. 2. Roovers M, Oudjama Y, Kaminska KH, Purta E, Caillet J, Droogmans L, Bujnicki JM. Sequence-structure-function analysis of the bifunctional enzyme MnmC that catalyses the last two steps in the biosynthesis of hypermodified nucleoside mnm5s2U in tRNA. Proteins. 2008 Jun;71(4):2076-85. doi: 10.1002/prot.21918. PubMed PMID: 18186482. 3. Durant PC, Bajji AC, Sundaram M, Kumar RK, Davis DR. Structural effects of hypermodified nucleosides in the Escherichia coli and human tRNALys anticodon loop: the effect of nucleosides s2U, mcm5U, mcm5s2U, mnm5s2U, t6A, and ms2t6A. Biochemistry. 2005 Jun 7;44(22):8078-89. PubMed PMID: 15924427. 4. Hagervall TG, Björk GR. Genetic mapping and cloning of the gene (trmC) responsible for the synthesis of tRNA (mnm5s2U)methyltransferase in Escherichia coli K12. Mol Gen Genet. 1984;196(2):201-7. PubMed PMID: 6387395.

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Keywords

Mnm5s2U 32860-54-1 mnm-5s2U mnm 5s2U inhibitor inhibit

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