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Melarsomine

Catalog No. T38686 CAS 128470-15-5

Melarsomine, a trivalent arsenical compound, is employed as an adulticide for canine heartworm disease and other helminth infections. It has significant utility in the research of these conditions.

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Melarsomine, CAS 128470-15-5

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Melarsomine, a trivalent arsenical compound, is employed as an adulticide for canine heartworm disease and other helminth infections. It has significant utility in the research of these conditions.

In vivo

The administration of Melarsomine at a dosage of 2.5 mg/kg via deep intramuscular injection, in conjunction with Doramectin, effectively eradicated D. repens infections in dogs[1]. Similarly, a lower dose of Melarsomine (0.25 mg/kg; deep i.m. injection) was successful in treating T. evansi infections in camels[2], while a slightly higher dose (0.5 mg/kg; deep i.m. injection) proved effective for T. evansi infections in dairy cattle in Thailand[2].

Molecular Weight	428.41
Formula	C13H21AsN8S2
CAS No.	128470-15-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Baneth G, et, al. Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin. Vet Parasitol. 2002 Apr 30;105(2):173-8. 2. Desquesnes M, et, al. An evaluation of melarsomine hydrochloride efficacy for parasitological cure in experimental infection of dairy cattle with Trypanosoma evansi in Thailand. Parasitology. 2011 Aug;138(9):1134-42.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Melarsomine 128470-15-5 inhibitor inhibit

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