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Magnaldehyde B

Catalog No. TN6656 CAS 92829-72-6

Magnaldehyde B is a natural lipase inhibitor(IC50= 96.96 uM). Magnaldehyde B can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.

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Magnaldehyde B, CAS 92829-72-6

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5 mg	Inquiry	$ 900.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 920.00

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Description	Magnaldehyde B is a natural lipase inhibitor(IC50= 96.96 uM). Magnaldehyde B can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent.
In vitro	Lipase is the key enzyme for catalyzing triglyceride hydrolysis in vivo, and lipase inhibitors have been used in the management of obesity. METHODS AND RESULTS:We present the first report on the use of lipase-adsorbed halloysite nanotubes as an efficient medium for the selective enrichment of lipase inhibitors from natural products. A simple and rapid approach was proposed to fabricate lipase-adsorbed nanotubes through electrostatic interaction. Results showed that more than 85% lipase was adsorbed into nanotubes in 90 min, and approximately 80% of the catalytic activity was maintained compared with free lipase. The specificity and reproducibility of the proposed approach were validated by screening a known lipase inhibitor (i.e., orlistat) from a mixture that contains active and inactive compounds. Moreover, we applied this approach with high performance liquid chromatography-mass spectrometry technique to screen lipase inhibitors from the Magnoliae cortex extract, a medicinal plant used for treating obesity. Two novel biphenyl-type natural lipase inhibitors magnotriol A and Magnaldehyde B were identified, and their IC50 values were determined as 213.03 and 96.96 μM, respectively. CONCLUSIONS: The ligand-enzyme interactions of Magnaldehyde B were further investigated by molecular docking. Our findings proved that enzyme-adsorbed nanotube could be used as a feasible and selective affinity medium for the rapid screening of enzyme inhibitors from complex mixtures.
Source	Natural Products > Magnoliaceae > Magnolia

Molecular Weight	280.323
Formula	C18H16O3
CAS No.	92829-72-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fabrication of enzyme-immobilized halloysite nanotubes for affinity enrichment of lipase inhibitors from complex mixtures. J Chromatogr A. 2015 May 1;1392:20-7.

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Magnaldehyde B 92829-72-6 inhibitor inhibit

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