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ML355

Catalog No. T4347   CAS 1532593-30-8

ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.

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ML355 Chemical Structure
ML355, CAS 1532593-30-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 45.00
2 mg In stock $ 64.00
5 mg In stock $ 103.00
10 mg In stock $ 163.00
25 mg In stock $ 332.00
50 mg In stock $ 549.00
100 mg In stock $ 789.00
500 mg In stock $ 1,630.00
1 mL * 10 mM (in DMSO) In stock $ 103.00
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Purity: 99.26%
Purity: 98.2%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
Targets&IC50 12-Lipoxygenase(12-LOX):0.34 μM
Molecular Weight 441.52
Formula C21H19N3O4S2
CAS No. 1532593-30-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (124.57 mM)

TargetMolReferences and Literature

1. Luci DK, et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23;57(2):495-506. 2. Zhang XJ, et al. An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury. Nat Med. 2018 Jan;24(1):73-83.

TargetMolCitations

1. Gao S, Zhou L, Lu J, et al. Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis. Oxidative Medicine and Cellular Longevity. 2022, 2022.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Obesity Compound Library Inhibitor Library Preclinical Compound Library Ferroptosis Compound Library Bioactive Compound Library Anti-Metabolism Disease Compound Library Lipid Metabolism Compound Library Bioactive Compounds Library Max Anti-COVID-19 Compound Library

Related Products

Related compounds with same targets
Efletirizine Pinusolide 6-Hydroxyflavanone 2-TEDC Shogaol Picrinine 3-Hydroxycoumarin 4-Aminosalicylic acid

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Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ML355 1532593-30-8 Metabolism Lipoxygenase ML-355 LOX Inhibitor ML 355 inhibit inhibitor

 

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