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MK436

Catalog No. T33434 CAS 33450-08-7

Synonyms: MK 436, MK-436

MK436 is a therapeutic agent and an antigenic animal drug that is effective in the treatment of Trypanosoma cruzonii infection.

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MK436, CAS 33450-08-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

MK436 is a therapeutic agent and an antigenic animal drug that is effective in the treatment of Trypanosoma cruzonii infection.

Synonyms	MK 436, MK-436
Molecular Weight	250.25
Formula	C11H14N4O3
CAS No.	33450-08-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jennings FW, Atouguia JM, Murray M. Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436. Trop Med Int Health. 1996 Oct;1(5):590-8. PubMed PMID: 8911443. 2. Jennings FW. Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin. Trop Med Parasitol. 1991 Sep;42(3):157-60. PubMed PMID: 1801135. 3. Andrade SG, Silva RC, Santiago CM. Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bull World Health Organ. 1989;67(5):509-14. PubMed PMID: 2515007; PubMed Central PMCID: PMC2491297. 4. Andrade SG, Silva RC, Santiago CM, Freitas LA. Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study. Bull World Health Organ. 1987;65(5):625-33. PubMed PMID: 3123082; PubMed Central PMCID: PMC2491062.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MK436 33450-08-7 MK 436 MK-436 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.