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MALT1 inhibitor MI-2

Catalog No. T2350 CAS 1047953-91-2

Synonyms: MI 2, MALT1 inhibitor, MI 2 (MALT1 inhibitor)

MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MALT1 inhibitor MI-2, CAS 1047953-91-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
Targets&IC50	MALT1:5.84 μM
Kinase Assay	High-Throughput Screening for MALT1 Proteolytic Activity Inhibitors: Ac-LRSR-AMC is used as substrate and reactions are measured with excitation/emission wavelengths of 360/465 nm. Two time points are measured for each reaction to eliminate false positives due to compound autofluorescence. The final percent inhibition is calculated with the formula {[fluorescencetest compound (T2-T1)-fluorescenceneg ctrl (T2-T1)]/[fluorescencepos ctrl (T2-T1)-fluorescenceneg ctrl (T2-T1)]} × 100, where Z-VRPR-FMK (300 nM) is used as positive control and buffer only as negative control. The positive hits are validated in concentration-response experiments within a dose range of 0.122–62.5 μM to determine IC50 of the compounds. Activity is validated using recombinant full-length wild-type MALT1.
Cell Research	Cell proliferation is determined by ATP quantification using a luminescent method and trypan blue dye exclusion. Standard curves for each cell line are calculated by plotting the cell number (determined using trypan blue) against their luminescence values, and cell number is calculated accordingly. Cell viability in drug-treated cells is normalized to their respective controls (fractional viability), and results are given as 1-fractional viability. CompuSyn software is used to determine GI25 and GI50 values.(Only for Reference)

Synonyms	MI 2, MALT1 inhibitor, MI 2 (MALT1 inhibitor)
Molecular Weight	455.72
Formula	C19H17Cl3N4O3
CAS No.	1047953-91-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45.6 mg/mL (100 mM)

Ethanol: 9.1 mg/mL (20 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fontan L, et al. Cancer Cell. 2012, 22(6), 812-824.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library Inhibitor Library Immunology/Inflammation Compound Library Covalent Inhibitor Library Anti-Cancer Active Compound Library NF-κB Signaling Compound Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Aging Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

MLT-943 MLT-943 JNJ-67856633 JNJ-67856633 MALT1 inhibitor MI-2 MALT1 inhibitor MI-2 MRE3008F20 MRE3008F20

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MALT1 inhibitor MI-2 1047953-91-2 免疫与炎症 MALT inhibit MALT1 MI 2 (MALT1 inhibitor) MALT1 inhibitor MI 2 Inhibitor MALT-1 inhibitor MI-2 MALT1 inhibitor MI 2 mucosa associated lymphoid tissue lymphoma translocation gene 1 MALT1 inhibitor MI2 inhibitor

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