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MALT1 inhibitor MI-2

MALT1 inhibitor MI-2
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Purity:99.87%
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MALT1 inhibitor MI-2

Catalog No. T2350Cas No. 1047953-91-2
MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
2 mg$54In Stock
5 mg$98In Stock
10 mg$131In Stock
25 mg$253In Stock
50 mg$441In Stock
100 mg$649In Stock
500 mg$1,390In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Related Compound Libraries of "MALT1 inhibitor MI-2"

Product Introduction

Bioactivity
Description
MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
In vitro
Daily intraperitoneal injection of 25 mg/kg MI-2 effectively inhibits the growth of TMD8 and HBL-1 ABC-DLBCL xenografts, while it has no effect on the growth of OCI-Ly1 tumors.
In vivo
MI-2 demonstrates excellent cellular permeability and inhibits the function of MALT1 in the ABC-DLBCL cell lines. It selectively inhibits the growth of MALT1-dependent cell lines, with GI50 values of 0.2, 0.5, 0.4, and 0.4 μM in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, respectively. Conversely, ABC-DLBCL cell lines not dependent on MALT1, such as U2932 and HLY-1, along with two types of GCB-DLBCL cell lines, exhibit resistance to MI-2.
Kinase Assay
High-Throughput Screening for MALT1 Proteolytic Activity Inhibitors: Ac-LRSR-AMC is used as substrate and reactions are measured with excitation/emission wavelengths of 360/465 nm. Two time points are measured for each reaction to eliminate false positives due to compound autofluorescence. The final percent inhibition is calculated with the formula {[fluorescencetest compound (T2-T1)-fluorescenceneg ctrl (T2-T1)]/[fluorescencepos ctrl (T2-T1)-fluorescenceneg ctrl (T2-T1)]} × 100, where Z-VRPR-FMK (300 nM) is used as positive control and buffer only as negative control. The positive hits are validated in concentration-response experiments within a dose range of 0.122–62.5 μM to determine IC50 of the compounds. Activity is validated using recombinant full-length wild-type MALT1.
Cell Research
Cell proliferation is determined by ATP quantification using a luminescent method and trypan blue dye exclusion. Standard curves for each cell line are calculated by plotting the cell number (determined using trypan blue) against their luminescence values, and cell number is calculated accordingly. Cell viability in drug-treated cells is normalized to their respective controls (fractional viability), and results are given as 1-fractional viability. CompuSyn software is used to determine GI25 and GI50 values.(Only for Reference)
AliasMALT1 inhibitor, MI 2, MI 2 (MALT1 inhibitor)
Chemical Properties
Molecular Weight455.72
FormulaC19H17Cl3N4O3
Cas No.1047953-91-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 55 mg/mL (120.69 mM)
Ethanol: 9.1 mg/mL (20 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.1943 mL10.9716 mL21.9433 mL109.7165 mL
5 mM0.4389 mL2.1943 mL4.3887 mL21.9433 mL
10 mM0.2194 mL1.0972 mL2.1943 mL10.9716 mL
DMSO
1mg5mg10mg50mg
20 mM0.1097 mL0.5486 mL1.0972 mL5.4858 mL
50 mM0.0439 mL0.2194 mL0.4389 mL2.1943 mL
100 mM0.0219 mL0.1097 mL0.2194 mL1.0972 mL

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