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MALT1 inhibitor MI-2

Catalog No. T2350   CAS 1047953-91-2
Synonyms: MI 2, MALT1 inhibitor, MI 2 (MALT1 inhibitor)

MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.

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MALT1 inhibitor MI-2, CAS 1047953-91-2
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
Targets&IC50 MALT1:5.84 μM
Kinase Assay High-Throughput Screening for MALT1 Proteolytic Activity Inhibitors: Ac-LRSR-AMC is used as substrate and reactions are measured with excitation/emission wavelengths of 360/465 nm. Two time points are measured for each reaction to eliminate false positives due to compound autofluorescence. The final percent inhibition is calculated with the formula {[fluorescencetest compound (T2-T1)-fluorescenceneg ctrl (T2-T1)]/[fluorescencepos ctrl (T2-T1)-fluorescenceneg ctrl (T2-T1)]} × 100, where Z-VRPR-FMK (300 nM) is used as positive control and buffer only as negative control. The positive hits are validated in concentration-response experiments within a dose range of 0.122–62.5 μM to determine IC50 of the compounds. Activity is validated using recombinant full-length wild-type MALT1.
Cell Research Cell proliferation is determined by ATP quantification using a luminescent method and trypan blue dye exclusion. Standard curves for each cell line are calculated by plotting the cell number (determined using trypan blue) against their luminescence values, and cell number is calculated accordingly. Cell viability in drug-treated cells is normalized to their respective controls (fractional viability), and results are given as 1-fractional viability. CompuSyn software is used to determine GI25 and GI50 values.(Only for Reference)
Synonyms MI 2, MALT1 inhibitor, MI 2 (MALT1 inhibitor)
Molecular Weight 455.72
Formula C19H17Cl3N4O3
CAS No. 1047953-91-2


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45.6 mg/mL (100 mM)

Ethanol: 9.1 mg/mL (20 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fontan L, et al. Cancer Cell. 2012, 22(6), 812-824.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Preclinical Compound Library Inhibitor Library Immunology/Inflammation Compound Library Covalent Inhibitor Library Anti-Cancer Active Compound Library NF-κB Signaling Compound Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Aging Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
MLT-943 MLT-943 JNJ-67856633 JNJ-67856633 MALT1 inhibitor MI-2 MALT1 inhibitor MI-2 MRE3008F20 MRE3008F20

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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