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Lu49888 HCl

Catalog No. T32912 CAS 109293-20-1

Synonyms: Azidopamil, LU49888, LU 49888, Ludopamil, LU-49888

LU 49888 is a photoaffinity analog of verapamil that has been used to identify specific binding sites for phenylalkylamines of calcium channels present in rabbit skeletal muscle microsomes.

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Lu49888 HCl, CAS 109293-20-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

LU 49888 is a photoaffinity analog of verapamil that has been used to identify specific binding sites for phenylalkylamines of calcium channels present in rabbit skeletal muscle microsomes.

Synonyms	Azidopamil, LU49888, LU 49888, Ludopamil, LU-49888
Molecular Weight	502.06
Formula	C26H36ClN5O3
CAS No.	109293-20-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Sieber M, Nastainczyk W, Zubor V, Wernet W, Hofmann F. The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel. Eur J Biochem. 1987 Aug 17;167(1):117-22. PubMed PMID: 2441986. 2. Striessnig J, Knaus HG, Grabner M, Moosburger K, Seitz W, Lietz H, Glossmann H. Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel. FEBS Lett. 1987 Feb 23;212(2):247-53. PubMed PMID: 2434359. 3. Qian XD, Beck WT. Binding of an optically pure photoaffinity analogue of verapamil, LU-49888, to P-glycoprotein from multidrug-resistant human leukemic cell lines. Cancer Res. 1990 Feb 15;50(4):1132-7. PubMed PMID: 1967551. 4. Striessnig J, Glossmann H, Catterall WA. Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9108-12. PubMed PMID: 2174553; PubMed Central PMCID: PMC55113.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lu49888 HCl 109293-20-1 Azidopamil LU49888 LU 49888 Ludopamil Lu-49888 HCl LU-49888 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.