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Lipoxin A4

Catalog No. T36051 CAS 89663-86-5

Synonyms: LXA4

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM.2 LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.[2],[3],[4] Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.[5]

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Lipoxin A4, CAS 89663-86-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	LXA4
Molecular Weight	352.471
Formula	C20H32O5
CAS No.	89663-86-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): 0.05 mg/mL

Ethanol: 50 mg/mL

References and Literature

1. Serhan, C.N., Nicolaou, K.C., Webber, S.E., et al. Lipoxin A. Stereochemistry and biosynthesis. J. Biol. Chem. 261(35), 16340-16345 (1986). 2. Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc. Natl. Acad. Sci. U.S.A. 81(17), 5335-5339 (1984). 3. Ramstedt, U., Serhan, C.N., Nicolaou, K.C., et al. Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: Studies on stereospecificity of inhibition and mode of action. J. Immunol. 138(1), 266-270 (1987). 4. Maddox, J.F., and Serhan, C.N. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: Selective inactivation by dehydrogenation and reduction. J. Exp. Med. 183(1), 137-146 (1996). 5. Serhan, C. . (2007).

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Keywords

Lipoxin A4 89663-86-5 Lipoxin A-4 LXA4 LXA-4 LXA 4 inhibitor inhibit

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