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Linaclotide acetate

Catalog No. T11852L CAS 851199-60-5

Synonyms: MM 416775, MM416775 MD-1100 acetate, Linzess, MM-416775

Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.

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Linaclotide acetate, CAS 851199-60-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	MM 416775, MM416775 MD-1100 acetate, Linzess, MM-416775
Molecular Weight	1586.79
Formula	C61H83N15O23S6
CAS No.	851199-60-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Layer P, Stanghellini V. Review article: Linaclotide for the management of irritable bowel syndrome with constipation. Aliment Pharmacol Ther. 2014 Feb;39(4):371-84. doi: 10.1111/apt.12604. Epub 2014 Jan 16. Review. PubMed PMID: 24433216; PubMed Central PMCID: PMC4305214. 2. Lacy BE, Schey R, Shiff SJ, Lavins BJ, Fox SM, Jia XD, Blakesley RE, Hao X, Cronin JA, Currie MG, Kurtz CB, Johnston JM, Lembo AJ. Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial. PLoS One. 2015 Jul 29;10(7):e0134349. doi: 10.1371/journal.pone.0134349. eCollection 2015. PubMed PMID: 26222318; PubMed Central PMCID: PMC4519259. 3. Castro J, Harrington AM, Hughes PA, Martin CM, Ge P, Shea CM, Jin H, Jacobson S, Hannig G, Mann E, Cohen MB, MacDougall JE, Lavins BJ, Kurtz CB, Silos-Santiago I, Johnston JM, Currie MG, Blackshaw LA, Brierley SM. Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate. Gastroenterology. 2013 Dec;145(6):1334-46.e1-11. doi: 10.1053/j.gastro.2013.08.017. Epub 2013 Aug 16. PubMed PMID: 23958540. 4. Love BL, Johnson A, Smith LS. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71(13):1081-91. doi: 10.2146/ajhp130575. Review. PubMed PMID: 24939497.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Linaclotide acetate 851199-60-5 MM416775 MD 1100 Acetate MM416775 MD-1100 Acetate MM 416775 MM416775 MD1100 Acetate MM416775 MM416775 MD-1100 acetate Linzess MM-416775 Linaclotide Acetate inhibitor inhibit

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