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Ligupurpuroside A

Catalog No. TN1868 CAS 147396-01-8

Ligupurpuroside A has Antioxidant,and hypoLipidemic effects, it can significantly inhibit Lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.

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Ligupurpuroside A, CAS 147396-01-8

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Purity: 98%

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Description

Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.

In vitro

The present study was carried out to characterize the antioxidants present in the bitter tea brewed from the leaves of LP. It was found that the crude glycoside fraction possessed strong protection against oxidation of human low-density lipoprotein (LDL). The column chromatographic separation led to the isolatation of five phenylethanoid glycosides, namely, acteoside, Ligupurpuroside A, cis-ligupurpuroside B, trans-ligupurpuroside B, and osmanthuside B. When acteoside was heated in the boiling water, it was isomerized to form isoacteoside. Acteoside, isoacteoside, and Ligupurpuroside A purified from LP were protective, whereas cis-ligupurpuroside B, trans-ligupurpuroside B, and osmanthuside B exhibited no protection to human LDL from Cu(2+)-medicated oxidation. Acteoside, isoacteoside, and Ligupurpuroside A were also effective in preventing the peroxyl free radical-induced oxidation of alpha-tocopherol in human LDL. The antioxidant activities of acteoside, isoacteoside, and Ligupurpuroside A were comparable to that observed for a green tea antioxidant, (-)-epicatechin gallate. The inhibitory effect of these three phenylethanoid glycosides on oxidation of human LDL and alpha-tocopherol was dose-dependent at concentrations of 5-40 microM.

Molecular Weight	770.734
Formula	C35H46O19
CAS No.	147396-01-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens.J Agric Food Chem. 2001 Jun;49(6):3113-9.

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Keywords

Ligupurpuroside A 147396-01-8 Chromatin/Epigenetic Metabolism PI3K/Akt/mTOR signaling AMPK LDL Inhibitor inhibitor inhibit

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