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Ledaborbactam etzadroxil

Catalog No. T39288 CAS 1842399-68-1

Synonyms: VNRX-7145

Ledaborbactam etzadroxil (VNRX-7145) is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ledaborbactam etzadroxil Chemical Structure

Ledaborbactam etzadroxil, CAS 1842399-68-1

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Biological Description

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Description

Ledaborbactam etzadroxil (VNRX-7145) is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes.

In vivo

Upon administering Ledaborbactam etzadroxil (VNRX-7145) to mice, dogs, and monkeys, the compound consistently shows oral bioavailability (F = 61-82%) across these species, with dosages ranging from 5-10 mg/kg[1]. It is rapidly metabolized in the intestinal S9 fractions of all tested species, except for beagle dogs, displaying short half-lives. The human plasma half-life is notably brief at approximately 11 minutes, aligning more closely with rodents than with the longer half-lives observed in dogs (43.9 minutes) and monkeys (22.0 minutes)[1]. In vivo efficacy against lethal murine septicemia was achieved when Ledaborbactam etzadroxil was orally co-administered with Ceftibuten, yielding an ED50 value of 12.9 mg/kg[1].

Synonyms	VNRX-7145
Molecular Weight	391.23
Formula	C19H26BNO7
CAS No.	1842399-68-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Robert E Trout, et al. Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes. J Med Chem. 2021 Jul 22;64(14):10155-10166.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ledaborbactam etzadroxil 1842399-68-1 VNRX7145 VNRX 7145 VNRX-7145 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.