Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lanicemine (AZD6765) dihydrochloride is a low-trapping blocker of the NMDA channel with Ki of 0.56-2.1 μM for NMDA receptor and IC 50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine (AZD6765) dihydrochloride has sustained antidepressant efficacy [1].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 34.00 |
Description | Lanicemine (AZD6765) dihydrochloride is a low-trapping blocker of the NMDA channel with Ki of 0.56-2.1 μM for NMDA receptor and IC 50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine (AZD6765) dihydrochloride has sustained antidepressant efficacy [1]. |
In vivo | Lanicemine is a low-trapping NMDA channel blocker that produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1]. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits that generate the gamma- electroencephalography (EEG), but affects these networks without the broader systems-level disruptions typical of ketamine [1]. Animal Model: Male Sprague-Dawley rats [1] Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: A clear dose-dependent elevation in spontaneous gamma-band EEG was produced, but only gamma changes for Ketamine were strongly associated with increases in locomotor activity. |
Molecular Weight | 271.19 |
Formula | C13H16Cl2N2 |
CAS No. | 153322-06-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Lanicemine dihydrochloride 153322-06-6 inhibitor inhibit