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Crenigacestat

Catalog No. T3633    CAS 1421438-81-4    Synonyms: LY3039478

LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.

Pack Size Availability Price/USD Quantity
1 mg In stock 55.00
2 mg In stock 99.00
5 mg Inquiry 159.00
10 mg Inquiry 263.00
25 mg Inquiry 492.00
50 mg Inquiry 767.00
1 mL * 10 mM (in DMSO) Inquiry 160.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.

Receptor:

Notch-1;

Chemical Information:
Molecular Weight 464.44
Formula C22H23F3N4O4
CAS Number 1421438-81-4
Solubility

DMSO: ≥34 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.