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LEQ-506 HCl (1204975-42-7 free base)

Catalog No. T24400 CAS T24400

Synonyms: LEQ-506, LEQ-506 dihychloride, NPVLEQ 506, LEQ506, LEQ-506 HCl, LEQ 506

LEQ506 is an orally bioavailable small-molecule Smoothened antagonist. It also has a potential antineoplastic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

LEQ-506 HCl (1204975-42-7 free base) Chemical Structure

LEQ-506 HCl (1204975-42-7 free base), CAS T24400

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

LEQ506 is an orally bioavailable small-molecule Smoothened antagonist. It also has a potential antineoplastic activity.

Synonyms	LEQ-506, LEQ-506 dihychloride, NPVLEQ 506, LEQ506, LEQ-506 HCl, LEQ 506
Molecular Weight	512.48
Formula	C27H31Cl2N5O
CAS No.	T24400

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tu J, Li JJ, Song LT, Zhai HL, Wang J, Zhang XY. Molecular modeling study on resistance of WT/D473H SMO to antagonists LDE-225 and LEQ-506. Pharmacol Res. 2018 Mar;129:491-499. doi: 10.1016/j.phrs.2017.11.025. Epub 2017 Nov 21. PubMed PMID: 29175550. 2. Lauressergues E, Heusler P, Lestienne F, Troulier D, Rauly-Lestienne I, Tourette A, Ailhaud MC, Cathala C, Tardif S, Denais-Laliève D, Calmettes MT, Degryse AD, Dumoulin A, De Vries L, Cussac D. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214. doi: 10.1002/prp2.214. eCollection 2016 Apr. PubMed PMID: 27069629; PubMed Central PMCID: PMC4804317.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LEQ-506 HCl (1204975-42-7 free base) T24400 NPVLEQ506 LEQ-506 LEQ-506 dihychloride NPVLEQ 506 LEQ506 NPVLEQ-506 1204975-42-7 LEQ-506 HCl LEQ 506 LEQ506 HCl (1204975427 free base) 1204975-42-7 free base LEQ 506 HCl (1204975 42 7 free base) inhibitor inhibit

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