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L-368899 free base

Catalog No. T24370 CAS 148927-60-0

Synonyms: L 368899, L 368,899, L368,899, L-368899, L368899, L-368,899

L-368899 is a non-peptide and orally active antagonist of oxytocin receptor (IC50: 8.9 nM). It displays 40-fold selectivity over vasopressin V1a and V2 receptors (IC50: 370 and 570 nM respectively).

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L-368899 free base, CAS 148927-60-0

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Biological Description

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Description

L-368899 is a non-peptide and orally active antagonist of oxytocin receptor (IC50: 8.9 nM). It displays 40-fold selectivity over vasopressin V1a and V2 receptors (IC50: 370 and 570 nM respectively).

Synonyms	L 368899, L 368,899, L368,899, L-368899, L368899, L-368,899
Molecular Weight	554.77
Formula	C26H42N4O5S2
CAS No.	148927-60-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kang SW, Jayanthi S, Nagarajan G, Suresh Kumar TK, Kuenzel WJ. Identification of avian vasotocin receptor subtype-specific antagonists involved in the stress response of the chicken, Gallus gallus. J Biomol Struct Dyn. 2018 May 17:1-15. doi: 10.1080/07391102.2018.1464957. [Epub ahead of print] PubMed PMID: 29658387. 2. Kotani M, Shimono K, Yoneyama T, Nakako T, Matsumoto K, Ogi Y, Konoike N, Nakamura K, Ikeda K. An eye tracking system for monitoring face scanning patterns reveals the enhancing effect of oxytocin on eye contact in common marmosets. Psychoneuroendocrinology. 2017 Sep;83:42-48. doi: 10.1016/j.psyneuen.2017.05.009. Epub 2017 May 10. PubMed PMID: 28586711. 3. Taylor JH, Cavanaugh J, French JA. Neonatal oxytocin and vasopressin manipulation alter social behavior during the juvenile period in Mongolian gerbils. Dev Psychobiol. 2017 Jul;59(5):653-657. doi: 10.1002/dev.21533. Epub 2017 May 31. PubMed PMID: 28561891; PubMed Central PMCID: PMC5523843. 4. Boulet NP, Cloutier CJ, Ossenkopp KP, Kavaliers M. Oxytocin, social factors, and the expression of conditioned disgust (anticipatory nausea) in male rats. Behav Pharmacol. 2016 Dec;27(8):718-725. PubMed PMID: 27740965.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L-368899 free base 148927-60-0 L 368899 L 368,899 L368,899 L368899 free base L-368899 L368899 L-368,899 L 368899 free base inhibitor inhibit

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