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L 659,877

Catalog No. T20148 CAS 125989-12-0

Synonyms: L 659877, L-659,877, L-659877, L659,877, L659877

L 659,877 is an antagonist of the Tachykinin and neurokinin-2 receptor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

L 659,877, CAS 125989-12-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

L 659,877 is an antagonist of the Tachykinin and neurokinin-2 receptor.

Synonyms	L 659877, L-659,877, L-659877, L659,877, L659877
Molecular Weight	762.92
Formula	C38H50N8O7S
CAS No.	125989-12-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Chen X, Yu L, Steill JD, Oomens J, Polfer NC. Effect of peptide fragment size on the propensity of cyclization in collision-induced dissociation: oligoglycine b(2)-b(8). J Am Chem Soc. 2009 Dec 30;131(51):18272-82. doi: 10.1021/ja9030837. PubMed PMID: 19947633. 2. Li H, Bao Y, Zhao Z. Expression of tachykinin receptors inXenopus oocytes injected with poly (A)(+) RNA from cat dorsal root ganglion. Sci China C Life Sci. 1998 Apr;41(2):139-45. doi: 10.1007/BF02882718. PubMed PMID: 18726197. 3. Minowa S, Tsuchiya S, Someya A, Horie S, Murayama T. Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain. Eur J Pharmacol. 2004 Feb 23;486(3):317-24. PubMed PMID: 14985054. 4. Gaspar MN, Ribeiro CA, Cunha-Vaz JG, Macedo TR. Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits. Pharmacology. 2004 Mar;70(3):152-9. PubMed PMID: 14752235.

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L 659,877 125989-12-0 L 659877 L-659,877 L-659877 L659,877 L659877 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.