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L 644711

Catalog No. T24299 CAS 81997-33-3

Synonyms: DPOFA, L644711, B-3(+), L-644,711, L-644711

L 644711 is an antagonist of HCO3(-)/Cl(-) antiporter.

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L 644711, CAS 81997-33-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

L 644711 is an antagonist of HCO3(-)/Cl(-) antiporter.

Synonyms	DPOFA, L644711, B-3(+), L-644,711, L-644711
Molecular Weight	369.24
Formula	C18H18Cl2O4
CAS No.	81997-33-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Iserovich P, Qin Q, Petrukhin K. DPOFA, a Cl⁻/HCO₃⁻ exchanger antagonist, stimulates fluid absorption across basolateral surface of the retinal pigment epithelium. BMC Ophthalmol. 2011 Nov 15;11:33. doi: 10.1186/1471-2415-11-33. PubMed PMID: 22085910; PubMed Central PMCID: PMC3271048. 2. Kimelberg HK. Volume activated anion channel and astrocytic cellular edema in traumatic brain injury and stroke. Adv Exp Med Biol. 2004;559:157-67. PubMed PMID: 18727237. 3. Zhang Y, Zhang H, Feustel PJ, Kimelberg HK. DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra. Exp Neurol. 2008 Apr;210(2):514-20. doi: 10.1016/j.expneurol.2007.11.027. Epub 2007 Dec 7. PubMed PMID: 18206872; PubMed Central PMCID: PMC2362851. 4. Rutledge EM, Aschner M, Kimelberg HK. Pharmacological characterization of swelling-induced D-[3H]aspartate release from primary astrocyte cultures. Am J Physiol. 1998 Jun;274(6 Pt 1):C1511-20. PubMed PMID: 9696693.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L 644711 81997-33-3 B-3 B3 DPOFA L644711 B 3 B-3(+) L-644,711 L-644711 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.