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L 644257

Catalog No. T32451 CAS 68354-99-4

Synonyms: L-644257, 6-Coham, Nmanchol, L644257

L 644257 is a synthetic glycolipid for study liposomes in vivo.

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L 644257, CAS 68354-99-4

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

L 644257 is a synthetic glycolipid for study liposomes in vivo.

Synonyms	L-644257, 6-Coham, Nmanchol, L644257
Molecular Weight	664.03
Formula	C39H69NO5S
CAS No.	68354-99-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ponpipom MM, Hagmann WK, O'Grady LA, Jackson JJ, Wood DD, Zweerink HJ. Glycolipids as host resistance stimulators. J Med Chem. 1990 Feb;33(2):861-7. PubMed PMID: 2299649. 2. Hagmann WK, Ponpipom MM, Jackson JJ, Wood DD, Boltz RC Jr, Zweerink HJ. Steroidal glycolipid, L-644,257, is a potent enhancer of nonspecific host resistance. Int J Immunopharmacol. 1990;12(2):241-6. PubMed PMID: 2329016. 3. Schwendener RA, Lagocki PA, Rahman YE. The effects of charge and size on the interaction of unilamellar liposomes with macrophages. Biochim Biophys Acta. 1984 Apr 25;772(1):93-101. PubMed PMID: 6712952. 4. Wu MS, Robbins JC, Bugianesi RL, Ponpipom MM, Shen TY. Modified in vivo behavior of liposomes containing synthetic glycolipids. Biochim Biophys Acta. 1981 Apr 17;674(1):19-29. PubMed PMID: 7236728.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L 644257 68354-99-4 L-644257 6-Coham Nmanchol L644257 inhibitor inhibit

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