Powder: -20°C for 3 years | In solvent: -80°C for 1 year
K00546, a potent inhibitor of both cyclin-dependent kinase (CDK1 and CDK2) and CDC2-like kinase (CLK1 and CLK3), demonstrates high specificity with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Additionally, it inhibits CLK1 and CLK3 with IC50s of 8.9 nM and 29.2 nM, respectively [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 265.00 | |
25 mg | 6-8 weeks | $ 920.00 | |
50 mg | 6-8 weeks | $ 1,180.00 | |
100 mg | 6-8 weeks | $ 1,820.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 320.00 |
Description | K00546, a potent inhibitor of both cyclin-dependent kinase (CDK1 and CDK2) and CDC2-like kinase (CLK1 and CLK3), demonstrates high specificity with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Additionally, it inhibits CLK1 and CLK3 with IC50s of 8.9 nM and 29.2 nM, respectively [1] [2] [3]. |
In vitro | K00546 binds to the SLK ATP-binding site and forms three hydrogen bonds with the kinase hinge residues E109 and C111. The sulphamoyl moiety of K00546 also interacts with the main chain of L40 [1]. K00546 (compound 3n) also inhibits PKA, casein kinase-1, MAP kinase (ERK-2), calmodulin kinase, VEGF-R2, GSK-3 and PDGF-Rβ with IC 50 values of 5.2 μM, 2.8 μM, 1.0 μM, 8.9 μM, 0.032 μM, 0.14 μM and 1.6 μM, respectively [2]. |
Molecular Weight | 425.44 |
Formula | C15H13F2N7O2S2 |
CAS No. | 443798-47-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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K 00546 443798-47-8 K-00546 K00546 inhibitor inhibit