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KX1-004

Catalog No. T1812 CAS 518058-84-9

Synonyms: KX1 004, KX1004

KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.

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KX1-004, CAS 518058-84-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 490.00
100 mg	In stock	$ 690.00
500 mg	In stock	$ 1,450.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.42%

Purity: 99.12%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.
Targets&IC50	Src PTK:40 μM
Kinase Assay	The Lck HTRF kinase assay involves ATP-dependent phosphorylation of a biotinylated substrate peptide of gastrin in the presence or absence of inhibitor compound. The final concentration of gastrin is 1.2 μM. The final concentration of ATP is 0.5 μM (Km app =0.6±0.1 μM), and the final concentration of Lck (a GST-kinase domain fusion (AA 225?509)) is 250 pM. Buffer conditions are as follows: 50 mM HEPES pH=7.5, 50 mM NaCl, 20 mM MgCl2, 5 mM MnCl2, 2 mM DTT, 0.05% BSA. The assay is quenched and stopped with 160 μL of detection reagent. Detection reagents are as follows: Buffer made of 50 mM Tris, pH=7.5, 100 mM NaCl, 3 mM EDTA, 0.05% BSA, 0.1% Tween20. Prior to reading, Streptavidin allophycocyanin (SA-APC) is added at a final concentration in the assay of 0.0004 mg/mL, along with europilated anti-phosphotyrosine Ab (Eu-anti-PY) at a final conc of 0.025 nM. The assay plate is read in a Discovery fluorescence plate reader with excitation at 320 nm and emission at 615 and 655 nm[1].

Synonyms	KX1 004, KX1004
Molecular Weight	284.29
Formula	C16H13FN2O2
CAS No.	518058-84-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (211.05 mM)

References and Literature

1. Harris KC, et al. Hear Res. 2005 Oct;208(1-2):14-25.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Metabolism Compound Library Kinase Inhibitor Library Reprogramming Compound Library HIF-1 Signaling Pathway Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Fluorochemical Library Angiogenesis related Compound Library

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Related compounds with same targets

KW-2449 Dasatinib hydrochloride PP2 HPK1-IN-2 MNS Inulicin PD173074 Ibrutinib

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KX1-004 518058-84-9 Angiogenesis Tyrosine Kinase/Adaptors Src noise cells inhibit hearing KX1 004 exposure KX1004 Inhibitor KX 1004 KX-1004 loss KX-1-004 hair inhibitor

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