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Jionoside B1

Name: Jionoside B1
Brand: TargetMol
SKU: TQ0226
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0226 Copy Product Info

Purity: 99.44%

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Jionoside B1 is a natural product and an α-glucosidase inhibitor with potential anti-diabetic activity. This compound, isolated from the herb Eriophyton wallichii, exhibits favorable enzyme inhibitory effects and may be used for the development of novel hypoglycemic agents.

Cas No. 120406-37-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$81	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$367	In Stock	In Stock
25 mg	$595	In Stock	In Stock
50 mg	$862	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.44%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Jionoside B1 is a natural product and an α-glucosidase inhibitor with potential anti-diabetic activity. This compound, isolated from the herb Eriophyton wallichii, exhibits favorable enzyme inhibitory effects and may be used for the development of novel hypoglycemic agents.
In vitro	Methods: In MDA-MB-231 and 4T1 cells, the synergistic effect of Jionoside B1 (10 μM, 6–24 h) combined with cisplatin (20 μM) was assessed by CCK-8, flow cytometry, and Western blot. Results: Jionoside B1 reduced the cisplatin IC50 from 22.86 μM to 9.17 μM (MDA-MB-231), significantly increased ROS levels, decreased mitochondrial membrane potential, upregulated Bax, cleaved caspase-3, and PARP, and induced apoptosis.[1]
In vivo	Methods: In a 4T1 orthotopic breast cancer BALB/c mouse model (5 × 10⁶ cells inoculated), mice were randomized after tumors reached 100 mm³ and received daily intraperitoneal injections of Jionoside B1 (5 mg/kg, dissolved in PBS) combined with cisplatin (2 mg/kg) for 14 consecutive days. Results: Combined administration significantly inhibited tumor growth, reduced tumor weight, increased cleaved PARP expression, and did not exacerbate hepatic or renal toxicity. [1]

Chemical Properties

Molecular Weight	814.78
Formula	C₃₇H₅₀O₂₀
Cas No.	120406-37-3
Smiles	[H][C@@]1(O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(OC)c(O)c3)O[C@H](CO[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@H]2OC(=O)\C=C\c2ccc(O)c(OC)c2)O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Relative Density.	1.56g/cm3

Storage & Solubility Information

Storage

Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (294.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2273 mL	6.1366 mL	12.2733 mL	61.3663 mL
5 mM	0.2455 mL	1.2273 mL	2.4547 mL	12.2733 mL
10 mM	0.1227 mL	0.6137 mL	1.2273 mL	6.1366 mL
20 mM	0.0614 mL	0.3068 mL	0.6137 mL	3.0683 mL
50 mM	0.0245 mL	0.1227 mL	0.2455 mL	1.2273 mL
100 mM	0.0123 mL	0.0614 mL	0.1227 mL	0.6137 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.