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JWH-251

Catalog No. T32341 CAS 864445-39-6

JWH 251, a cannabimimetic indole, has a high affinity tothe central cannabinoid (CB1) receptor (Ki = 29 nM) and a comparatively modest affinity for the peripheral cannabinoid (CB2) receptor (Ki = 146 nM). JWH 251 can stimulates GTPγS and bind to CB1 and CB2 receptors with EC50 values of 29 and 8.3 nM, respectively.

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JWH-251, CAS 864445-39-6

Pack Size	Availability	Price/USD
5 mg	35 days	$ 175.00
10 mg	35 days	$ 328.00
25 mg	35 days	$ 770.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	319.44
Formula	C22H25NO
CAS No.	864445-39-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Göl E, Çok İ. Assessment of types of synthetic cannabinoids in narcotic cases assessed by the Council of Forensic Medicine between 2011-2015, Ankara, Turkey. Forensic Sci Int. 2017 Nov;280:124-129. doi: 10.1016/j.forsciint.2017.09.017. Epub 2017 Oct 4. PubMed PMID: 29028489. 2. Strano-Rossi S, Anzillotti L, Dragoni S, Pellegrino RM, Goracci L, Pascali VL, Cruciani G. Metabolism of JWH-015, JWH-098, JWH-251, and JWH-307 in silico and in vitro: a pilot study for the detection of unknown synthetic cannabinoids metabolites. Anal Bioanal Chem. 2014 Jun;406(15):3621-36. doi: 10.1007/s00216-014-7793-9. Epub 2014 May 8. PubMed PMID: 24804821. 3. Kavanagh P, Grigoryev A, Melnik A, Savchuk S, Simonov A, Rozhanets V. Detection and tentative identification of urinary phase I metabolites of phenylacetylindole cannabimimetics JWH-203 and JWH-251, by GC-MS and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:102-8. doi: 10.1016/j.jchromb.2013.07.005. Epub 2013 Jul 15. PubMed PMID: 23917406. 4. Hutter M, Kneisel S, Auwärter V, Neukamm MA. Determination of 22 synthetic cannabinoids in human hair by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:95-101. doi: 10.1016/j.jchromb.2012.07.002. Epub 2012 Jul 17. PubMed PMID: 22835826.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JWH-251 864445-39-6 JWH251 JWH 251 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.