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JH-IX-179

Catalog No. T32288 CAS T32288

Synonyms: JH-IX179, JH-IX 179

JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autophosphorylation of FLT3 and activity of downstream signaling molecules of FLT3-D835Y and FLT3-ITD.

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JH-IX-179, CAS T32288

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	JH-IX179, JH-IX 179
Molecular Weight	436.52
Formula	C26H24N6O
CAS No.	T32288

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor. John M. Hatcher, Ellen Weisberg, Taebo Sim, Richard M. Stone, Suiyang Liu, James D. Griffin, and Nathanael S. Gray. Publication Date (Web): March 8, 2016 (Letter). DOI: 10.1021/acsmedchemlett.5b00498

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Keywords

JH-IX-179 T32288 JH-IX179 JH-IX 179 JH IX 179 JHIX179 inhibitor inhibit

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