Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, thereby reducing TTR transcript levels. Inotersen sodium holds potential for research on hereditary TTR amyloidosis polyneuropathy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 1,550.00 | |
10 mg | Inquiry | $ 2,320.00 |
Description | Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, thereby reducing TTR transcript levels. Inotersen sodium holds potential for research on hereditary TTR amyloidosis polyneuropathy. |
In vitro | Inotersen sodium, at concentrations ranging from 0.16 to 20 μM over a 16-hour period, effectively decreases TTR mRNA levels in HepG2 cells in a dose-dependent manner[1]. |
In vivo | Inotersen sodium, administered subcutaneously at doses ranging from 10-100 mg/kg twice weekly for 4 weeks, significantly reduces plasma transthyretin (TTR) protein levels by over 80% in transgenic mice carrying the Ile84Ser human TTR mutation[1]. |
Synonyms | ISIS-420915 sodium |
Molecular Weight | N/A |
CAS No. | 1432726-13-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Inotersen sodium 1432726-13-0 ISIS-420915 sodium inhibitor inhibit