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Importazole HCl (662163-81-7 free base)

Catalog No. T3445L CAS T3445L

Synonyms: Importazole hydrochloride, Importazole HCl, Importazole

Importazole specifically inhibits the importin-β likely by altering its interaction with RanGTP.

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Importazole HCl (662163-81-7 free base) Chemical Structure

Importazole HCl (662163-81-7 free base), CAS T3445L

Pack Size	Availability	Price/USD
100 mg	Inquiry	$ 459.00
200 mg	Inquiry	$ 789.00
500 mg	Inquiry	$ 1,368.00
1 g	Inquiry	$ 2,444.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Importazole specifically inhibits the importin-β likely by altering its interaction with RanGTP.

Synonyms	Importazole hydrochloride, Importazole HCl, Importazole
Molecular Weight	354.88
Formula	C20H23ClN4
CAS No.	T3445L

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Soderholm JF, Bird SL, Kalab P, Sampathkumar Y, Hasegawa K, Uehara-Bingen M, Weis K, Heald R. Importazole, a small molecule inhibitor of the transport receptor importin-β. ACS Chem Biol. 2011 Jul 15;6(7):700-8. doi: 10.1021/cb2000296. Epub 2011 Apr 21. PubMed PMID: 21469738; PubMed Central PMCID: PMC3137676. 2. Mojica SA, Hovis KM, Frieman MB, Tran B, Hsia RC, Ravel J, Jenkins-Houk C, Wilson KL, Bavoil PM. SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors. Mol Biol Cell. 2015 May 15;26(10):1918-34. doi: 10.1091/mbc.E14-11-1530. Epub 2015 Mar 18. PubMed PMID: 25788290; PubMed Central PMCID: PMC4436835. 3. Yan W, Li R, He J, Du J, Hou J. Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis. Cell Signal. 2015 Apr;27(4):851-9. doi: 10.1016/j.cellsig.2015.01.013. Epub 2015 Jan 30. PubMed PMID: 25643631. 4. Bird SL, Heald R, Weis K. RanGTP and CLASP1 cooperate to position the mitotic spindle. Mol Biol Cell. 2013 Aug;24(16):2506-14. doi: 10.1091/mbc.E13-03-0150. Epub 2013 Jun 19. PubMed PMID: 23783028; PubMed Central PMCID: PMC3744954.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Importazole HCl (662163-81-7 free base) T3445L Importazole HCl (662163817 free base) Importazole HCl (662163 81 7 free base) Importazole hydrochloride Importazole HCl Importazole Hydrochloride 662163-81-7 free base 662163-81-7 Importazole inhibitor inhibit

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