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Ici 200880

Catalog No. T25521 CAS 105080-50-0

Synonyms: Ici 200,880, Ici-200880, Ici200,880, Ic-200,880, Ici200880

Ici 200880 is a human neutrophil elastase synthetic peptide inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ici 200880, CAS 105080-50-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ici 200880 is a human neutrophil elastase synthetic peptide inhibitor.

Synonyms	Ici 200,880, Ici-200880, Ici200,880, Ic-200,880, Ici200880
Molecular Weight	687.13
Formula	C30H34ClF3N4O7S
CAS No.	105080-50-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Williams JC, Stein RL, Giles RE, Krell RD. Biochemistry and pharmacology of ICI 200,880, a synthetic peptide inhibitor of human neutrophil elastase. Ann N Y Acad Sci. 1991;624:230-43. PubMed PMID: 2064224. 2. Davis PC, Wildonger RA, Veale HS. A specific radioimmunoassay for the measurement of ICI 200,880, an elastase inhibitor, in human serum. J Pharm Biomed Anal. 1993 Jul;11(7):549-56. PubMed PMID: 8399528. 3. Williams JC, Falcone RC, Knee C, Stein RL, Strimpler AM, Reaves B, Giles RE, Krell RD. Biologic characterization of ICI 200,880 and ICI 200,355, novel inhibitors of human neutrophil elastase. Am Rev Respir Dis. 1991 Oct;144(4):875-83. PubMed PMID: 1928965. 4. Mehta JL, Nichols WW, Nicolini FA, Hendricks J, Donnelly WH, Saldeen TG. Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog. Cardiovasc Res. 1994 Jul;28(7):947-56. PubMed PMID: 7954605.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ici 200880 105080-50-0 Ici 200,880 Ici-200880 Ici200,880 Ic-200,880 Ici200880 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.