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Ibutamoren Mesylate

Catalog No. T7112   CAS 159752-10-0
Synonyms: MK-677, 伊布莫仑甲磺酸盐, MK-0677

Ibutamoren Mesylate is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.

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Ibutamoren Mesylate, CAS 159752-10-0
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ibutamoren Mesylate is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.
In vivo Following oral administration Ibutamoren Mesylate(MK0677) amplifies episodic GH release.?Mechanistically, it synergizes with growth hormone releasing hormone (GHRH) through a receptor and signal transduction pathway distinct from that of GHRH and is a functional antagonist of somatostatin (SRIF).?MK0677 also acts on the arcuate nucleus and appears to stimulate GHRH release.?By using 35S-MK0677, a new G-protein coupled receptor for MK0677 was characterized in the plasma membrane fraction of pituitary and hypothalamic tissue.?The receptor is present in very low abundance and couples to phospholipase C. Other ligands selective for this receptor also cause synchronization of well-defined pathways leading to GH release.?Repeated oral treatment of dogs once daily with MK0677 initiates amplified pulsatile GH release accompanied by increases in IGF-1 that are sustained.?The unique biological properties of MK0677 and other synthetic ligands that bind to the same receptor force us to predict that these ligands mimic a naturally occurring hormone that regulates pulsatile GH release[1].
Synonyms MK-677, 伊布莫仑甲磺酸盐, MK-0677
Molecular Weight 624.77
Formula C28H40N4O8S2
CAS No. 159752-10-0


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (80.03 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Smith R G , Pong S S , Hickey G , et al. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland[J]. Recent Progress in Hormone Research, 1996, 51:261-85; discussion 285-6. 2. Aydemir M , Durap F , Kayan C , et al. Insulin-Like Growth Factor-1 and Growth Hormone (GH) Levels in Canine Cerebrospinal Fluid are Unaffected by GH or GH Secretagogue (MK-0677) Administration[J]. Hormone and Metabolic Research, 1999, 31(02/03):133-137.

Related compound libraries

This product is contained In the following compound libraries:
GPCR Compound Library Inhibitor Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Clinical Compound Library

Related Products

Related compounds with same targets
Capromorelin Tartrate CJC-1295 acetate(863288-34-0 free base) Obestatin (rat) acetate Human growth hormone-releasing factor acetate AnaMorelin hydrochloride Ibutamoren Mesylate Pralmorelin acetate 158861-67-7(free base) TC-G-1008

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