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Ibutamoren Mesylate

Catalog No. T7112 CAS 159752-10-0

Synonyms: MK-677, 伊布莫仑甲磺酸盐, MK-0677

Ibutamoren Mesylate is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ibutamoren Mesylate, CAS 159752-10-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ibutamoren Mesylate is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.

In vivo

Following oral administration Ibutamoren Mesylate(MK0677) amplifies episodic GH release.?Mechanistically, it synergizes with growth hormone releasing hormone (GHRH) through a receptor and signal transduction pathway distinct from that of GHRH and is a functional antagonist of somatostatin (SRIF).?MK0677 also acts on the arcuate nucleus and appears to stimulate GHRH release.?By using 35S-MK0677, a new G-protein coupled receptor for MK0677 was characterized in the plasma membrane fraction of pituitary and hypothalamic tissue.?The receptor is present in very low abundance and couples to phospholipase C. Other ligands selective for this receptor also cause synchronization of well-defined pathways leading to GH release.?Repeated oral treatment of dogs once daily with MK0677 initiates amplified pulsatile GH release accompanied by increases in IGF-1 that are sustained.?The unique biological properties of MK0677 and other synthetic ligands that bind to the same receptor force us to predict that these ligands mimic a naturally occurring hormone that regulates pulsatile GH release[1].

Synonyms	MK-677, 伊布莫仑甲磺酸盐, MK-0677
Molecular Weight	624.77
Formula	C28H40N4O8S2
CAS No.	159752-10-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (80.03 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Smith R G , Pong S S , Hickey G , et al. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland[J]. Recent Progress in Hormone Research, 1996, 51:261-85; discussion 285-6. 2. Aydemir M , Durap F , Kayan C , et al. Insulin-Like Growth Factor-1 and Growth Hormone (GH) Levels in Canine Cerebrospinal Fluid are Unaffected by GH or GH Secretagogue (MK-0677) Administration[J]. Hormone and Metabolic Research, 1999, 31(02/03):133-137.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Capromorelin Tartrate CJC-1295 acetate(863288-34-0 free base) Obestatin (rat) acetate Human growth hormone-releasing factor acetate AnaMorelin hydrochloride Ibutamoren Mesylate Pralmorelin acetate 158861-67-7(free base） TC-G-1008

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ibutamoren Mesylate 159752-10-0 G蛋白偶联受体 GHSR MK 0677 MK 677 Inhibitor Ibutamoren MK677 inhibit MK-677 Growth hormone secretagogue receptor MK-0677 MK0677 inhibitor

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