Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ibutamoren Mesylate is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.
Description | Ibutamoren Mesylate is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. |
In vivo | Following oral administration Ibutamoren Mesylate(MK0677) amplifies episodic GH release.?Mechanistically, it synergizes with growth hormone releasing hormone (GHRH) through a receptor and signal transduction pathway distinct from that of GHRH and is a functional antagonist of somatostatin (SRIF).?MK0677 also acts on the arcuate nucleus and appears to stimulate GHRH release.?By using 35S-MK0677, a new G-protein coupled receptor for MK0677 was characterized in the plasma membrane fraction of pituitary and hypothalamic tissue.?The receptor is present in very low abundance and couples to phospholipase C. Other ligands selective for this receptor also cause synchronization of well-defined pathways leading to GH release.?Repeated oral treatment of dogs once daily with MK0677 initiates amplified pulsatile GH release accompanied by increases in IGF-1 that are sustained.?The unique biological properties of MK0677 and other synthetic ligands that bind to the same receptor force us to predict that these ligands mimic a naturally occurring hormone that regulates pulsatile GH release[1]. |
Synonyms | MK-677, 伊布莫仑甲磺酸盐, MK-0677 |
Molecular Weight | 624.77 |
Formula | C28H40N4O8S2 |
CAS No. | 159752-10-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 50 mg/mL (80.03 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Ibutamoren Mesylate 159752-10-0 G蛋白偶联受体 GHSR MK 0677 MK 677 Inhibitor Ibutamoren MK677 inhibit MK-677 Growth hormone secretagogue receptor MK-0677 MK0677 inhibitor