Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 μM. ITH15004 (1 μM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 182.00 | |
10 mg | Inquiry | $ 348.00 | |
25 mg | Inquiry | $ 730.00 |
Description | ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 μM. ITH15004 (1 μM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA). |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL
DMF: 20 mg/mL
DMF:PBS (pH 7.2) (1:3): 0.25 mg/mL
You can also refer to dose conversion for different animals. More
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ITH15004 ITH-15004 ITH 15004 inhibitor inhibit