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INCB059872

Catalog No. T39226 CAS 1802909-49-4

Synonyms: INCB059872

INCB059872 is a highly potent, orally active, selective, and irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1). Its chemical properties make it suitable for use in researching myeloid leukemia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

INCB059872, CAS 1802909-49-4

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5 mg	Inquiry	$ 970.00

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Biological Description

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Description	INCB059872 is a highly potent, orally active, selective, and irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1). Its chemical properties make it suitable for use in researching myeloid leukemia.
In vitro	INCB059872 (25 nM; 48 hours; 293T cells) increases enhancer activity and gene expression[1]. INCB059872 (25 nM; 24 hours; THP-1 cells) makes THP-1 show a growth defect within one cell doubling time or approximately 3 days. INCB059872 (100 nM; 24 hours; MV-4–11 cells) treated MV-4–11 cells continues to grow as DMSO-treated cells for multiple cell divisions. INCB059872 (THP-1 cells) regulates PRO-seq analysis identifies genes and enhancers[1]. Western Blot Analysis[1]Cell Line: 293T cells Concentration: 250 nM Incubation Time: 48 hours Result: Increased enhancer activity and gene expression.
In vivo	INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 days) administration in mice resulted in alterations in bone marrow progenitor populations, as identified by single-cell RNA sequencing[1].

Synonyms	INCB059872
Molecular Weight	386.536
Formula	C23H34N2O3
CAS No.	1802909-49-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Johnston G, et al. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene. 2020;752:144758.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

INCB059872 1802909-49-4 INCB 059872 INCB-059872 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.