store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM). IDX184 is a liver-targeted nucleotide prodrug with anti-HCV activity that inhibits HCV NS5B polymerase and can be used in combination with pegylated interferon-α2a and ribavirin for the primary treatment of chronic hepatitis C. It has been shown to inhibit HCV polymerase and nucleoside polymerase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 191.00 | |
5 mg | In stock | $ 480.00 | |
10 mg | In stock | $ 687.00 | |
25 mg | In stock | $ 1,080.00 | |
50 mg | In stock | $ 1,480.00 |
Description | IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM). IDX184 is a liver-targeted nucleotide prodrug with anti-HCV activity that inhibits HCV NS5B polymerase and can be used in combination with pegylated interferon-α2a and ribavirin for the primary treatment of chronic hepatitis C. It has been shown to inhibit HCV polymerase and nucleoside polymerase. |
Targets&IC50 | HCV polymerase:0.31 μM (IC50), HCV polymerase:52.3 nM (Ki) |
In vitro |
IDX184, a liver-targeted prodrug of the nucleotide 2′-MeG-MP, serves as a hepatitis C virus polymerase inhibitor with liver-specific targeting.[1] IDX184 is not toxic (CC50>100μM) in any tested cell line.[2] IDX184 is a second-generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM).[2] |
Synonyms | IDX-184, IDX 184 |
Molecular Weight | 626.62 |
Formula | C25H35N6O9PS |
CAS No. | 1036915-08-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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IDX184 1036915-08-8 Microbiology/Virology Proteases/Proteasome HCV Protease IDX-184 IDX 184 inhibitor inhibit