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Hymeglusin

Catalog No. T27766 CAS 29066-42-0

Synonyms: L659,699, L 659,699, L-659,699

L-659,699, also known as hymeglusin, is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.

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Hymeglusin, CAS 29066-42-0

Pack Size	Availability	Price/USD
500 μg	35 days	$ 297.00
2500 μg	35 days	$ 1,240.00
1 mg	35 days	$ 528.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	L-659,699, also known as hymeglusin, is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme.
Targets&IC50	HMG-CoA:1.2 μM (IC50)

Synonyms	L659,699, L 659,699, L-659,699
Molecular Weight	324.41
Formula	C18H28O5
CAS No.	29066-42-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Skaff DA, Ramyar KX, McWhorter WJ, Barta ML, Geisbrecht BV, Miziorko HM. Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin. Biochemistry. 2012 Jun 12;51(23):4713-22. doi: 10.1021/bi300037k. PubMed PMID: 22510038; PubMed Central PMCID: PMC3431454. 2. Carazo A, Alejandre MJ, Louktibi A, Linares A. The reversal of the inhibition on lipids synthesis by L-659,699 in arterial smooth muscle cells cultures. Mol Cell Biochem. 2001 May;221(1-2):25-31. PubMed PMID: 11506182. 3. Ginger ML, Chance ML, Sadler IH, Goad LJ. The biosynthetic incorporation of the intact leucine skeleton into sterol by the trypanosomatid Leishmania mexicana. J Biol Chem. 2001 Apr 13;276(15):11674-82. PubMed PMID: 11148203. 4. Rokosz LL, Boulton DA, Butkiewicz EA, Sanyal G, Cueto MA, Lachance PA, Hermes JD. Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes. Arch Biochem Biophys. 1994 Jul;312(1):1-13. PubMed PMID: 7913309.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Hymeglusin 29066-42-0 L659,699 L 659,699 L-659,699 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.