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Hydroorotic acid

Catalog No. T32116 CAS 155-54-4

Synonyms: Dihydroorotic acid, L-Dihydroorotate

Hydroorotic acid, a derivative of orotic acid, can be used as an intermediate in pyrimidine biosynthesis.

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Hydroorotic acid, CAS 155-54-4

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50 mg	Inquiry	$ 291.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Hydroorotic acid, a derivative of orotic acid, can be used as an intermediate in pyrimidine biosynthesis.

Synonyms	Dihydroorotic acid, L-Dihydroorotate
Molecular Weight	158.11
Formula	C5H6N2O4
CAS No.	155-54-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tiwari K, Kumar R, Dubey VK. Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition. Biochimie. 2016 Dec;131:45-53. doi: 10.1016/j.biochi.2016.09.009. Epub 2016 Sep 17. PubMed PMID: 27650727. 2. Duley JA, Henman MG, Carpenter KH, Bamshad MJ, Marshall GA, Ooi CY, Wilcken B, Pinner JR. Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine. Mol Genet Metab. 2016 Sep;119(1-2):83-90. doi: 10.1016/j.ymgme.2016.06.008. Epub 2016 Jun 14. PubMed PMID: 27370710. 3. Alves CN, Silva JR, Roitberg AE. Insights into the mechanism of oxidation of dihydroorotate to orotate catalysed by human class 2 dihydroorotate dehydrogenase: a QM/MM free energy study. Phys Chem Chem Phys. 2015 Jul 21;17(27):17790-6. doi: 10.1039/c5cp02016f. Epub 2015 Jun 19. PubMed PMID: 26087682. 4. Peng WF, Huang CY. Allantoinase and dihydroorotase binding and inhibition by flavonols and the substrates of cyclic amidohydrolases. Biochimie. 2014 Jun;101:113-22. doi: 10.1016/j.biochi.2014.01.001. Epub 2014 Jan 10. PubMed PMID: 24418229.

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Keywords

Hydroorotic acid 155-54-4 Dihydroorotic acid L-Dihydroorotate inhibitor inhibit

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