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Hyaluronic acid

Catalog No. T3762 CAS 9004-61-9

Synonyms: Hyaluronate, hyaluronan

Hyaluronic acid (hyaluronan) is a glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances.

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Hyaluronic acid, CAS 9004-61-9

Pack Size	Availability	Price/USD
50 mg	In stock	$ 46.00
100 mg	In stock	$ 64.00
200 mg	In stock	$ 84.00
500 mg	In stock	$ 139.00
1 g	In stock	$ 175.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Hyaluronic acid (hyaluronan) is a glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances.
In vitro	Hyaluronic acid (HA) is extensively utilized across various medical fields due to its capacity to bind with numerous water molecules, thereby enhancing tissue hydration and mechanical resistance. Its significant roles include facilitating wound healing, ovulation, fertilization, signal transduction, and impacting tumor physiology, making it valuable in aesthetic medicine, joint disorder treatments like osteoarthritis and rheumatoid arthritis, and ophthalmology for its lubricative benefits on the corneal endothelium. High molecular mass HA impairs the chemotaxis and migration of inflammatory cells, thus serving as an effective barrier to inflammation and shielding from free radicals. Furthermore, HA contributes to aesthetic dermatology by minimizing mechanical damage to tissues with minimal side effects. Research also suggests its potential in identifying tumor markers, managing liver diseases, and application in pharmaceutical formulations. In cancer research, particularly digestive cancers, HA interactions with tumor cells may activate signaling pathways that promote proliferation, cell adhesion, migration, invasion, and contribute to angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like characteristics, and resistance to chemotherapy and radiation.
In vivo	HA (hyaluronic acid) is ubiquitous across biological fluids and tissues, with its beneficial effects on joint health evidenced by numerous animal studies. These studies have demonstrated that HA enhances cartilage matrix synthesis, prevents its degradation, mitigates inflammation, fosters the production of endogenous HA, and augments cartilage resilience and hydration. Additionally, topically applied high molecular weight HA formulations have been shown to expedite the healing of acute skin wounds and facilitate the recovery of venous leg ulcers, thereby offering a valuable option for chronic wound management.

Synonyms	Hyaluronate, hyaluronan
Molecular Weight	800000~1500000
Formula	(C14H21NO11)n
CAS No.	9004-61-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 14.29 mg/mL, Sonication is recommended.

References and Literature

1. Salwowska NM, et al. Physiochemical properties and application of hyaluronic acid: a systematic review. J Cosmet Dermatol. 2016 Dec;15(4):520-526. 2. Wu RL, et al. Hyaluronic acid in digestive cancers. J Cancer Res Clin Oncol. 2017 Jan;143(1):1-16. 3. Kogan G, et al. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett. 2007 Jan;29(1):17-25. 4. Zhu C, Zhang J, Zhang J, et al. Purification and characterization of chondroitinase ABC from Acinetobacter sp. C26[J]. International journal of biological macromolecules. 2017 Feb;95:80-86.

Citations

1. Zhu C, Zhang J, Zhang J, et al. Purification and characterization of chondroitinase ABC from Acinetobacter sp. C26. International journal of biological macromolecules. 2017 Feb;95:80-86. 2. Abbate I, Zappulla C, Santonocito M, et al. Preclinical study of a new matrix to help the ocular surface in dry eye disease. Experimental Eye Research. 2022: 109168 3. Han J, Zheng S, Jin J, et al.Polydopamine-loaded prunetin nanomaterials activate DRD2 to reduce UV-induced inflammation by stabilizing and promoting Nrf2 nuclear translocation.Acta Biomaterialia.2023 4. Zhao R, Zhang C, Yu L, et al.In Vitro Fermentation of Hyaluronan with Different Molecular Weights by Human Gut Microbiota: Differential Effects on Gut Microbiota Structure and Metabolic Function.Polymers.2023, 15(9): 2103. 5. Liu Y, Liu X, Zhang Y, et al.Interpenetrating Polymer Network HA/Alg-RGD Hydrogel: An Equilibrium of Macroscopic Stability and Microscopic Adaptability for 3D Cell Growth and Vascularization.Biomacromolecules.2023 6. Tian X J, Yin Z J, Li Z J, et al.Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.Advanced Science.2023: 2305913.

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Keywords

Hyaluronic acid 9004-61-9 Metabolism Others Endogenous Metabolite Inhibitor inhibit Hyaluronate hyaluronan inhibitor

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