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Hirsutanonol

Catalog No. TN4212 CAS 41137-86-4

Hirsutanonol is a secondary metabolite from the bark of Alnus glutinosa. Hirsutanonol has potent antioxidant and free radical scavenging activities and exhibits an inhibition effect on mitochondrial lipid peroxidation. Hirsutanonol can be used for studies

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Hirsutanonol, CAS 41137-86-4

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Description	Hirsutanonol is a secondary metabolite from the bark of Alnus glutinosa. Hirsutanonol has potent antioxidant and free radical scavenging activities and exhibits an inhibition effect on mitochondrial lipid peroxidation. Hirsutanonol can be used for studies
In vitro	Hirsutanonol shows significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.Hirsutanonol shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells, it also has a chemoprotective effect on human lymphocyte DNA. Hirsutanonol (1 µg/mL) decreased the frequency of micronuclei by 63.6 %, exerting a much stronger effect than the synthetic protector amifostine (17.2 %, 1 µg/mL)[1].
Source	Natural Products > Betulaceae > Alnus

Molecular Weight	346.37
Formula	C19H22O6
CAS No.	41137-86-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Diarylheptanoids from Alnus glutinosa bark and their chemoprotective effect on human lymphocytes DNA. Planta Med. 2013 Apr;79(6):499-505. 2. Cytotoxic activities of diarylheptanoids from Alnus japonica. Arch Pharm Res. 2008 Oct;31(10):1287-9. 3. Constituents and their DPPH Scavenging Activities from the Leaves of Alnus hirsuta (Spach) Rupr. Korean J. Medicinal Crop Sci.,2005,13(2):85-90.

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Keywords

Hirsutanonol 41137-86-4 Immunology/Inflammation Microbiology/Virology Neuroscience COX Antifection inhibitor inhibit

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