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HIE-124

Catalog No. T27543 CAS 805326-00-5

HIE-124 is a central cervous system active anticonvulsant and ultra-short acting hypnotic.

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HIE-124, CAS 805326-00-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

HIE-124 is a central cervous system active anticonvulsant and ultra-short acting hypnotic.

Molecular Weight	240.28
Formula	C10H12N2O3S
CAS No.	805326-00-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. El-Subbagh HI, El-Azab AS, Hassan GS, El-Messery SM, Abdel-Aziz AA, El-Taher KE. Thiadiazolodiazepine analogues as a new class of neuromuscular blocking agents: Synthesis, biological evaluation and molecular modeling study. Eur J Med Chem. 2017 Jan 27;126:15-23. doi: 10.1016/j.ejmech.2016.09.096. Epub 2016 Sep 30. PubMed PMID: 27744183. 2. El-Subbagh HI, Hassan GS, El-Taher KE, El-Messery SM, Al-Azab AS, Abdelaziz AA, Hefnawy MM. Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics. Eur J Med Chem. 2016 Nov 29;124:237-247. doi: 10.1016/j.ejmech.2016.08.038. Epub 2016 Aug 22. PubMed PMID: 27597405. 3. Al-Rashood ST, Hassan GS, El-Messery SM, El-Taher KE, Hefnawy MM, Al-Omar MA, El-Subbagh HI. Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents. Bioorg Med Chem Lett. 2016 Jan 15;26(2):445-53. doi: 10.1016/j.bmcl.2015.11.097. Epub 2015 Dec 7. PubMed PMID: 26706170. 4. Kadi A, Hefnawy M, Al-Majed A, Alonezi S, Asiri Y, Attia S, Abourashed E, El-Subbagh H. Liquid chromatographic high-throughput analysis of the new ultra-short acting hypnotic 'HIE-124' and its metabolite in mice serum using a monolithic silica column. Analyst. 2011 Feb 7;136(3):591-7. doi: 10.1039/c0an00381f. Epub 2010 Nov 16. PubMed PMID: 21079880.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HIE-124 805326-00-5 HIE124 HIE 124 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.