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HB007

Catalog No. T37646 CAS 2387821-46-5

HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].

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HB007, CAS 2387821-46-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 854.00
50 mg	6-8 weeks	$ 1,110.00
100 mg	6-8 weeks	$ 1,610.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].
In vitro	HB007 (compound 24), at concentrations ranging from 0.1 to 100 μM, effectively inhibits the growth of LN229 cells in a dose-dependent manner [t1]. Additionally, at concentrations between 10 and 25 μM, HB007 selectively decreases both the conjugation and overall protein levels of SUMO1, without affecting the levels of SUMO2/3 or ubiquitin (UB) in LN229 cells [t1].
In vivo	HB007 (compound 24) (25-50 mg/kg; intraperitoneally administered for 15 days) significantly reduced the growth of colon and lung tumors without affecting the mice's body weight[1].

Molecular Weight	328.78
Formula	C15H9ClN4OS
CAS No.	2387821-46-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486. 2. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HB007 2387821-46-5 HB-007 HB 007 inhibitor inhibit

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