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H2L5186303

Catalog No. T22835   CAS 139262-76-3
Synonyms: ZINC33388081

H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.

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H2L5186303 Chemical Structure
H2L5186303, CAS 139262-76-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 44.00
5 mg In stock $ 98.00
10 mg In stock $ 178.00
25 mg In stock $ 397.00
50 mg In stock $ 589.00
100 mg In stock $ 843.00
500 mg In stock $ 1,730.00
1 mL * 10 mM (in DMSO) In stock $ 116.00
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Purity: 97.23%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.
Targets&IC50 LPA 2 Receptor:9 nM (IC50)
In vitro The high cell invasion activity of HT1080-M6 cells is significantly suppressed by H2L5186303[1].
In vivo H2L5186303 shows strong suppressive efficacy when administered before OVA sensitization and challenge, such as suppression of airway hyper responsiveness, inflammatory cytokine levels, mucin production, and eosinophil numbers[2].
Synonyms ZINC33388081
Molecular Weight 488.45
Formula C26H20N2O8
CAS No. 139262-76-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL (409.5 mM), sonification is recommended.

TargetMolReferences and Literature

1. Takahashi K, et al. Lysophosphatidic acid receptor-2 (LPA2) and LPA5 regulate cellular functions during tumor progression in fibrosarcoma HT1080 cells. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2698-2703. 2. Lee YJ, Im DS. Efficacy Comparison of LPA2 Antagonist H2L5186303 and Agonist GRI977143 on Ovalbumin-Induced Allergic Asthma in BALB/c Mice. Int J Mol Sci. 2022 Aug 28;23(17):9745.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Bioactive Compounds Library Max Inhibitor Library

Related Products

Related compounds with same targets
Ki16198 GRI977143 DBIBB Ki16425 LX-1031 LPA1 receptor antagonist 1 H2L 5765834 TC LPA5 4

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Keywords

H2L5186303 139262-76-3 GPCR/G Protein LPA Receptor H2L-5186303 ZINC-33388081 H2L 5186303 ZINC33388081 ZINC 33388081 inhibitor inhibit

 

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