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Guattegaumerine

Catalog No. T39610 CAS 21446-35-5

Guattegaumerine, a bisbenzylisoquinoline alkaloid, exhibits antimitotic, cytotoxic, and neuroprotective activities.

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Guattegaumerine, CAS 21446-35-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Guattegaumerine, a bisbenzylisoquinoline alkaloid, exhibits antimitotic, cytotoxic, and neuroprotective activities.

In vitro

Gauttegaumerine administration (1.25-6.25 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) notably enhances cell viability at concentrations of 1.25 and 2.5μM. Pretreatment with guattegaumerine also significantly reduces LDH efflux[1]. At a concentration of 2.5 μM and the same pretreatment duration, guattegaumerine substantially diminishes oxidative stress-induced apoptosis in rat cortical neurons compared to the control group[1]. Furthermore, guattegaumerine, at doses ranging from 1.25 to 2.5 μM, effectively lowers the increase in Ca[2+]i prompted by H2O2 and KCl in cortical neurons[1].

Molecular Weight	596.724
Formula	C36H40N2O6
CAS No.	21446-35-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Qing Lü, et al. Guattegaumerine protects primary cultured cortical neurons against oxidative stress injury induced by hydrogen peroxide concomitant with serum deprivation. Cell Mol Neurobiol. 2009 May;29(3):355-64. 2. J Leclercq, et al. Antimitotic and cytotoxic activities of guattegaumerine, a bisbenzylisoquinoline alkaloid. Planta Med

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Keywords

Guattegaumerine 21446-35-5 inhibitor inhibit

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