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Genz-123346 free base

Catalog No. T4049 CAS 491833-30-8

Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.

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Genz-123346 free base Chemical Structure

Genz-123346 free base, CAS 491833-30-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 68.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 292.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 98.59%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
Targets&IC50	GM1:14 nM.
In vivo	GLPG-1690 was able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice and in reducing extracellular matrix deposition in the lung while also reducing LPA 18:2 content in bronchoalveolar lavage fluid.

Molecular Weight	418.57
Formula	C24H38N2O4
CAS No.	491833-30-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (119.45 mM)

References and Literature

1. Zhao H, et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes. 2007 May;56(5):1210-8. 2. Chai L, et al. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int J Oncol. 2011 Mar;38(3):701-11. 3. Shen W, et al. Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons. J Neurochem. 2014 Jun;129(5):884-94 4. Natoli TA, et al. Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med. 2010 Jul;16(7):788-92.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Glycometabolism Compound Library Anti-Metabolism Disease Compound Library Bioactive Compound Library Metabolism Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compounds Library Max Glycolysis Compound Library ReFRAME Related Library NO PAINS Compound Library

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Pinoresinol diacetate PF-04991532 Tuberosin WAY-640509 AMG-1694 PFK-015 YZ9 MitoPQ

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Genz-123346 free base 491833-30-8 Metabolism Glucokinase Inhibitor Genz 123346 free base Genz123346 free base Genz 123346 inhibit Genz123346 Genz-123346 inhibitor

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