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Ganoderic acid DM

Catalog No. TN1663   CAS 173075-45-1

Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.

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Ganoderic acid DM Chemical Structure
Ganoderic acid DM, CAS 173075-45-1
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1 mg 35 days $ 275.00
5 mg 35 days $ 950.00
10 mg 35 days $ 1,750.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.
In vitro GADM effectively inhibited cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells. GADM both concentration- and time-dependently mediated G1 cell cycle arrest and significantly decreased the protein level of CDK2, CDK6, cycle D1, p-Rb and c-Myc in MCF-7 cells. Moreover, GADM obviously induced DNA fragmentation and cleavage of PARP which are the characteristics of apoptosis and decreased the mitochondrial membrane potential in MCF-7 cells. Besides, we also showed that GADM elicited DNA damage as measured by comet assay which is a sensitive method for DNA damage detection. γ-H2AX, a marker of DNA damage, was also slightly up-regulated after treated with GADM for 6h, suggesting that the G1 cell cycle arrest and apoptosis induced by GADM may be partially resulted from GADM-induced DNA damage[1]
Molecular Weight 468.67
Formula C30H44O4
CAS No. 173075-45-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells.Fitoterapia. 2012 Mar;83(2):408-14.

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Keywords

Ganoderic acid DM 173075-45-1 Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair Endocrinology/Hormones PARP CDK Androgen Receptor inhibitor inhibit

 

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