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Ganoderic acid DM

Catalog No. TN1663 CAS 173075-45-1

Synonyms: 灵芝酸 DM, 灵芝酸DM

Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion.

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Ganoderic acid DM, CAS 173075-45-1

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Purity: 98%

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Description

In vitro

GADM effectively inhibited cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells. GADM both concentration- and time-dependently mediated G1 cell cycle arrest and significantly decreased the protein level of CDK2, CDK6, cycle D1, p-Rb and c-Myc in MCF-7 cells. Moreover, GADM obviously induced DNA fragmentation and cleavage of PARP which are the characteristics of apoptosis and decreased the mitochondrial membrane potential in MCF-7 cells. Besides, we also showed that GADM elicited DNA damage as measured by comet assay which is a sensitive method for DNA damage detection. γ-H2AX, a marker of DNA damage, was also slightly up-regulated after treated with GADM for 6h, suggesting that the G1 cell cycle arrest and apoptosis induced by GADM may be partially resulted from GADM-induced DNA damage[1]

Synonyms	灵芝酸 DM, 灵芝酸DM
Molecular Weight	468.67
Formula	C30H44O4
CAS No.	173075-45-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells.Fitoterapia. 2012 Mar;83(2):408-14.

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Keywords

Ganoderic acid DM 173075-45-1 DNA损伤和修复表观遗传内分泌与激素细胞周期 PARP Androgen Receptor CDK Inhibitor inhibitor inhibit

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